Increasing Sleep Duration: A Novel Approach to Weight Control

描述(由申请人提供)： 在肥胖症流行的同时，也出现了睡眠时间短的流行病。流行病学研究已经证明了睡眠时间短与肥胖和肥胖相关的健康问题(包括高血压、糖尿病和死亡率)之间的联系，基础实验室研究已经确定了可能解释这种联系的生理机制。然而，到目前为止，还没有研究睡眠时间变化对体重变化的影响的干预研究。本申请中提出的行为干预发展中心(CBID)试图将关于睡眠持续时间的基础科学转化为一种新的干预措施，以减少肥胖和肥胖相关的共病。我们提出了一系列程序性研究，以开发睡眠+减肥干预措施。我们研究的目标人群将是年轻人(25-45岁)，他们的睡眠时间和肥胖之间的联系似乎最强，他们超重或肥胖(BIvii 25-40)，以及目前每晚睡眠不到6个半小时。这一系列研究将用来检验睡眠时间的增加以及与减肥计划相结合对饮食和锻炼行为的影响(客观测量)，最终对体重的影响。我们还将研究增加睡眠时间对生理、心理和认知变化的影响，这些变化可能与饮食和活动的变化以及对体重控制建议的遵守有关。拟议的CBID创建了一个新的跨学科团队，包括行为体重控制、睡眠的基本和临床方面、认知功能的功能磁共振成像和神经心理学评估、饮食和锻炼行为以及与睡眠和体重相关的生理变化等领域的调查人员。相关性：肥胖和睡眠时间短都是主要的健康问题，会带来各种负面后果。鉴于睡眠不足可能导致肥胖问题，这项建议寻求开发一种干预措施，以增加睡眠时间，并确定单独增加睡眠或与减肥计划结合使用是否对饮食、锻炼和最终控制体重产生积极影响。(摘要结束)

DESCRIPTION (provided by applicant): Simultaneous with the epidemic of obesity, there has been an epidemic of short sleep duration. Epidemiological studies have documented a link between short sleep duration and both obesity and obesity- related health problems including hypertension, diabetes, and mortality and basic laboratory studies have identified physiological mechanisms that may explain this association. However, to date, there have been no intervention studies examining the impact of changes in sleep duration on changes in body weight. The Center for Behavioral Intervention Development (CBID) proposed in this application seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. We propose a programmatic series of studies to develop a sleep + weight loss intervention. The target population for our studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BIVII 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. We will also examine the effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations. The proposed CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior, and physiological changes associated with sleep and weight. RELEVANCE: Both obesity and short sleep duration are major health problems, with a variety of negative consequences. Given that short sleep may contribute to the problem of obesity, this proposal seeks to develop an intervention to increase sleep duration and to determine whether increasing sleep alone, or in combination with a weight loss program, can have positive effects on eating, exercise, and ultimately weight control. (End of Abstract)