An Experimental Model of Human Language and Cognition in Drug Dependence

描述（由申请人提供）：K23辅导病人导向职业发展奖的候选人，Kenneth M. Carpenter博士，要求支持一个为期5年的培训和研究项目，旨在发展行为药理学实验方法和人类语言行为分析方面的专业知识，以调查人类语言行为和认知如何影响个人改变他们习惯性使用药物的过程。语言/认知过程在大多数人类活动中普遍存在，可以改变直接学习过程的效果。然而，很少有研究通过实验模拟人类语言和认知影响物质使用和行为改变的过程。人类语言和认知行为分析的新发展为在受控的实验室条件下直接研究语言/认知过程提供了理论基础和实验框架。该提案将为Carpenter博士提供必要的培训，以开发与药物使用相关的语言/认知过程建模的实验平台，并将这些模型转化为临床环境，以研究药物治疗期间语言/认知变化机制。Carpenter博士建议职业发展活动建立在他在临床心理学和研究方面的背景上，并利用哥伦比亚大学和纽约州精神病学研究所的资源来促进他成为一名独立临床研究者的长期目标。作为综合教育计划的一部分，卡彭特博士将在研究的道德行为、设计和实施结合人类行为药理学和语言行为研究方法分析的实验、心理语言学和心理治疗过程研究的指导、以及拨款的写作和管理等方面接受强化指导。短期目标是获得在人类实验室自我给药范式中适应和测试人类语言/认知实验模型的技能，并将该模型应用于临床环境中，以预测参与CBT干预的可卡因依赖患者的治疗结果。与公共卫生的相关性：可卡因的使用在美国相当普遍，并与严重的社会心理问题有关。确定促进行为改变的因素可以改善我们的预防和干预工作，并对公众健康产生积极影响。

DESCRIPTION (provided by applicant): The candidate of this K23 Mentored Patient-Oriented Career Development Award application, Kenneth M. Carpenter, Ph.D., requests support for a 5-year program of training and research aimed at developing expertise in the experimental methodologies of behavioral pharmacology and the analysis of human verbal behavior in order to investigate the processes by which human verbal behavior and cognition can affect individuals' attempts to change their habitual use of drugs. Vebal/Cognitive processes are pervasive in most human activities and can alter the effects of direct learning procedures. However, few studies have experimentally modeled the processes by which human language and cognition influence substance use and behavioral change. Exciting new developments in the behavioral analysis of human language and cognition offer a theoretical basis and experimental framework for directly investigating verbal/cognitive processes under controlled laboratory conditions. This proposal will provide Dr. Carpenter with the necessary training to develop an experimental platform for modeling the verbal/cognitive processes associated with drug use and translate these models to the clinical context to investigate verbal/cognitive mechanisms of change during drug treatment. Dr. Carpenter proposes career development activities that build on his background in clinical psychology and research and capitalize on the resources of Columbia University and New York State Psychiatric Institute to promote his long-term goal of becoming an independent clinical investigator. As part of a comprehensive educational plan, Dr. Carpenter will receive intensive mentoring in the ethical conduct of research, designing and conducting experiments that combine human behavioral pharmacology and the analysis of verbal behavior research methods, instruction in psycholinguistics and psychotherapy process research, and grant writing and management. The short-term goals are to acquire the skills to adapt and test an experimental model of human verbal/cognition in a human laboratory self-administration paradigm and employ this model in a clinical context to predict treatment outcome among cocaine dependent patients enrolled in a CBT intervention. Relevance to Public Health: Cocaine use is fairly prevalent in the US and is associated with significant psychosocial problems. Identifying factors that promote behavioral change can improve our prevention and intervention efforts and have a positive impact on public health.