Biostatistics and Data Management

生物统计和数据管理核心（核心D）将支持数据管理的所有阶段， 在P01项目中进行分析。它将创造和管理旧的和新的遗传，病理， 来自四项参与研究的问卷调查数据。它将制定和维持准备工作的程序， 并使用安全的方法在研究中分发数据集。它将与核心B和C合作， 项目负责人在研究设计和抽样方案的各种项目。它将提供方法论 和分析专业知识，包括研究设计，数据分析计划的执行， 生物信息学分析和统计结果的解释。核心将负责数据 协调一致，以便所有调查人员使用相同的变量定义。核心将执行许多 的数据分析，并拥有最先进的硬件和软件这样做。核心将与 与博士后研究员和研究人员密切合作。核心的领导者， 其他核心研究人员具有遗传学研究方面的专业知识，并在以下方面拥有丰富的经验： 管理和分析大型多中心研究的数据。核心活动将保持高水平 数据收集和分析的标准，保持数据的完整性，实现数据的一致性， 研究，并提高项目调查人员的生产力。

The Biostatistics and Data management Core, Core D, will support all phases of data management and analyses in this P01 project. It will create and manage both old and new genetic, pathologic, and questionnaire data from the four participating studies. It will develop and maintain procedures for preparing and distributing datasets across studies using secure methods. It will collaborate with Cores B and C and Project Leaders in study design and sampling schemes for the various Projects. It will provide methodologic and analytic expertise to project investigators including study design, conduct of data analytic plans, bioinformatics analyses, and interpretation of statistical results. The Core will be responsible for data harmonization so that all investigators are using the same variable definitions. The Core will carry out many of the data analyses and has state-of-the-art hardware and software for doing so. The Core will collaborate closely with postdoctoral fellows and investigators on the individual Projects. The Leader of the Core and other Core investigators have expertise in genetics research and have had extensive experience in managing and analyzing the data of large multicenter studies. The activities of the Core will maintain high standards for data collection and analysis, maintain the integrity of the data, achieve consistency across the studies, and increase the productivity of Project investigators.