Project 4 - Salk Institute for Biological Studies NINDS Center Core Grant

索尔克生物研究所请求支持神经科学新的Ceriter核心资助 Research.自20世纪60年代该研究所成立以来，神经科学已成为该研究所的主要研究领域。 索尔克学院的研究重点。超过一半的教师，领导.32研究所实验室，目前是 主要从事神经科学研究。教师的主要研究兴趣分为 几个广泛的计划领域：临床和转化神经科学，分子和细胞 神经科学、神经发育和系统神经科学。17个研究项目，支持 12名教师作为主要研究人员，目前由NINDS资助。这些奖项包括9个 独立的R 01/R37研究项目，积极的RC 2（大机会）奖，K99和POI 程序项目。九名索尔克调查员都是现任或前任雅各布·贾维茨获奖者。具体目标 该中心核心补助金申请的目的是为当前和未来所需的关键资源提供支持， 未来NINDS资助的研究项目。提出了三个新的核心资源：1）基因组 Manipulation Core，提供用于体内和体外模型的基因靶向ES细胞系的生产服务 用于基因和神经系统疾病的功能分析，2）成像核心，专注于专门的支持 用于TEM超微结构成像，并促进多个先进的 成像平台，以及3）行为核心，提供小动物行为方面的专业知识 不同测试模式的分析和一致性。这些核心的管理将首先关注 为Salk研究所的八名研究人员提供支持，目前NINDS资助的R 01/R37研究 程序.任何多余的核心能力将提供给索尔克研究所的其他研究人员， 拥有与NINDS的使命相一致的研究项目。该基础设施项目将 提供核心服务，促进不断发展的先进技术应用于 NINDS资助的索尔克研究所的研究项目，并利用现有资金作为资源乘数 更好地推进这些项目，解决与NINDS使命相关的重要问题。

The Salk Institute for Biological Studies requests support for a new Ceriter Core Grant for Neuroscience Research. Since the founding ofthe Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading.32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests ofthe faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a POI program project. Nine Salk investigators are either current or past Jacob Javits awardees. The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.