COPD EPIDEMIOLOGY WHOLE GENOME ANALYSIS PROJECT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 UCSD将作为一个研究中心参与一项多中心试验，其总体目标是进行一项全面的全基因组关联（GWA）研究，以确定影响COPD的基因。 所有参与研究中心和研究者的列表见附录A。 我们的主要假设是： 第一章 使用计算机断层扫描以及临床和生理测量对COPD受试者进行精确表征，将提供能够将广泛的COPD综合征分解为具有临床意义的亚型的见解。 （二） 全基因组关联研究将确定COPD易感性的遗传决定因素，从而深入了解临床相关的COPD亚型。 第三章 不同的遗传决定因素影响肺气肿和气道疾病的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UCSD will participate as one site in a multi center trial with the overall goal of conducting a comprehensive genome-wide association (GWA) study to identify genes influencing COPD. A list of all participating sites and the investigators is in Appendix A. Our primary hypotheses are: 1) Precise characterization of COPD subjects using computed tomography, as well as clinical and physiological measures, will provide insight that will enable the broad COPD syndrome to be decomposed into clinically significant subtypes. 2) Genome-wide association studies will identify genetic determinants for COPD susceptibility that will provide insight into clinically relevant COPD subtypes. 3) Distinct genetic determinants influence the development of emphysema and airway disease.