NEURAL DYSFUNCTION OF INTEROCEPTION IN ADOLESCENTS WITH ANOREXIA NERVOSA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的具体目标是： 目标1：前额叶（AI），眶额皮质（OFC）和相关区域整合味觉和内感受性意识的感觉/享乐方面的服务的稳态。我们假设AN患者限制饮食和体重减轻是因为可口的食物几乎没有奖励。 目标2：除了减肥，AN患者在生活中几乎没有什么回报，他们往往过度关注未来的后果。我们预测，生病的AN将表现出无法区分反映异常前腹侧纹状体（AVS）边缘功能的正反馈和负反馈。 目的3：AN倾向于刻板、不灵活和行为抑制。我们将使用停止任务（Band et al.，2003; Logan等人，1984;马修斯等人，2005）来表征抑制性运动控制的神经基质。我们假设，相对于CW，病态AN将显示出运动抑制所必需的额-底丘脑回路的需求特异性改变（Aron等人，2004年）。 目标4：在一个探索性的目的，我们建议研究如何临床，认知和个性/气质的措施可能与BOLD响应和/或完整的额纹状体连接使用扩散张量成像（DTI）确定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of the project are: AIM 1: The anterior insula (AI), orbitofrontal cortex (OFC), and associated regions integrate sensory/hedonic aspects of taste and interoceptive awareness in the service of homeostasis. We hypothesize that restricted eating and weight loss occur in AN because a palatable food elicits little reward. AIM 2: Little in life is rewarding to individuals with AN aside from weight loss, and they tend to be overconcerned with future consequences. We predict that ill AN will show an inability to discriminate positive and negative feedback reflecting aberrant anterior ventral striatum (AVS) limbic function. AIM 3: AN tend to be rigid, inflexible and behaviorally inhibited. We will use a stop task (Band et al., 2003; Logan et al., 1984; Matthews et al., 2005) to characterize the neural substrates of inhibitory motor control. We hypothesize that ill AN, relative to CW, will show a demand-specific alteration of a fronto-subthalamic circuit that is necessary for motor inhibition (Aron et al., 2004). AIM 4: In an exploratory aim, we propose to examine how clinical, cognitive, and personality/temperament measures might be correlated to either the BOLD response and/or the integrity of frontostriatal connectivity as determined using diffusion tensor imaging (DTI).