ANTIRETROVIRAL THERAPY AND THE HEPATITIS C VIRUS: A LIMITED CENTER TRIAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的假设是，在有效的抗逆转录病毒治疗过程中，丙型肝炎病毒/艾滋病毒感染者会增加病毒载量，病毒动力学模拟将证明丙型肝炎病毒载量的增加与病毒产量的增加直接相关。 主要目的是研究早期/晚期丙型肝炎病毒的动力学特征，以及丙型肝炎病毒载量增加的发生率、意义和发病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that HCV/HIV infected subjects will increase viral load during effective antiretroviral therapy and viral kinetic modeling will demonstrate that the increase in HCV viral load is directly related to to increased viral production. The primary objective is to characterize early/late HCV viral kinetics as well as the prevalence, significance, and pathogenesis of HCV viral load increase.