CNTN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 加州神经艾滋病组织网络(CNTN)是由五个加州医疗中心(加州大学圣地亚哥分校、加州大学旧金山分校、加州大学欧文分校、南加州大学/洛杉矶分校和雪松/洛杉矶分校)组成的联盟，计划在五年内收集300名艾滋病患者和75名对照组的神经精神病学数据(生前)和神经标本(尸检时)(对照组在世时没有登记和跟踪)。这些标本将被储存在一个储存库中，用于未来的研究，旨在了解艾滋病毒感染对神经系统的影响。 UCI的组成部分旨在识别、招募、招募和评估30名预期寿命不到一年的艾滋病患者。在这项为期五年的研究中，队列将维持在30名患者，取代那些死亡或退出研究的患者。每年将对大约6名患者进行尸检。在5年内，将在没有事先进行临床评估的情况下，对艾滋病和神经系统疾病患者进行额外的5-10次尸检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The California NeuroAIDS Tissue Network (CNTN) is a consortium of five (5) California medical centers (UC San Diego, UC San Francisco, UC Irvine, USC/LA County, and Cedars/UC Los Angeles) which proposes to collect neuropsychiatric data (prior to death) and neurologic specimens (at autopsy) from 300 AIDS patients and 75 controls over five years (controls are not enrolled and followed while alive). The specimens will be stored in a repository for use in future studies designed to understand the impact of HIV infection on the nervous system. The UCI component is designed to identify, recruit, enroll, and assess a cohort of 30 AIDS patients with life expectancies of less than one year. The cohort will be maintained at 30 patients throughout the five-year study by replacing those who die or drop out of the study. About 6 patients will be autopsied each year. Over 5 years, an additional 5-10 autopsies will be performed on patients with AIDS and neurologic diseases without prior clinical assessment.