Rodent Animal Biosafety Level 3 (ABSL3)

啮齿动物生物安全3级（ABSL）核心的目的是为研究者提供 有机会通过使用一个充分的 啮齿动物实验室小动物模型在传染性疾病的研究中发挥了关键作用， 对人类有重要意义的疾病。特别是，啮齿动物模型已成功地用于开发和 测试疫苗和其他预防策略，评估治疗剂的功效和毒性， 发展诊断学，探索发病机制。加州大学欧文分校的啮齿动物ABSL核心由一个国家组成- 最先进的、经过全面认证的ABSL设施，为研究人员提供资源，以进行A、B类研究 和C病原体，包括指定为特定病原体的病原体。虽然主要是为小动物设计的 工作，ABSL 3的组织，使非动物工作与选择代理也可以容纳。 通过充电程序，将向学术界和工业界的调查人员提供该设施的使用 在整个第九区及以外地区设立一个委员会，并制定一个程序，为潜在的 用户已经开发。此外，实验室的建立不仅提供空间，而且还提供培训， 专门的内部人员进行由主要研究者设计和监督的实验， UC Irvine或其他机构。该设施将提供机会进行气溶胶挑战研究， NIAID A、B或C类优先病原体和新发传染病，以便调查 致病机制和发展疫苗和快速诊断测试吸入的有机体。啮齿动物 ABSL的核心是实现两个具体目标：i）维护基础设施，以确保可用性 区域ABSL设施，供学术界和工业界的调查人员使用。核心将保持一个 空间分配程序和供设施使用和技术支持的补给装置; 2）建立和 在ABSL机构中维持一个小动物气溶胶激发装置。将进行实验， 验证该装置，表征雾化细菌的生物物理特性，并开发小鼠模型， 肺部感染，以推进吸入性感染的研究。啮齿动物ABSL核心将作为关键的 协作性发病机制、疫苗和诊断研究的区域资源。

The purpose of the Rodent Animal Biosafety Level 3 (ABSLs) Core is to provide investigators with the opportunity to advance research in bioterrorism and emerging infectious diseases through the use of a fully operational rodent facility. Small animal models have played a critical role in investigations of infectious diseases of importance to humans. In particular, rodent models have been successfully used to develop and test vaccines and other prevention strategies, to evaluate the efficacy and toxicity of therapeutic agents, to develop diagnostics, and to explore pathogenesis. The Rodent ABSLs Core at UC Irvine consists of a stateof- the-art, fully certified ABSLs facility offering investigators resources to conduct research on Category A, B and C pathogens, including those designated as select agents. Although designed primarily for small animal work, the ABSL3 is organized so that non-animal work with select agents can also be accommodated. Through a recharge procedure, use of the facility will be offered to investigators in academia and in industry throughout region IX and beyond; a committee and a process for allocating temporary space to potential users has been developed. Moreover, the laboratory is set up to provide not only space but also trained, dedicated in-house personnel to conduct experiments designed and supervised by Principal Investigators at UC Irvine or other institutions. The facility will offer the opportunity to conduct aerosol challenge studies of NIAID category A, B, or C priority pathogens and emerging infectious diseases in order to investigate pathogenic mechanisms and develop vaccines and rapid diagnostic tests of inhaled organisms. The Rodent ABSLs Core sets out to accomplish two specific aims: i) Maintain an infrastructure to ensure the availability of a regional ABSLs facility for use by investigators in academia and industry. The Core will maintain a process for space allocation and a recharge unit for facility use and for technical support; 2) Establish and maintain a small animal aerosol challenge unit in the ABSLs facility. Experiments will be conducted to validate the unit, characterize biophysical properties of aerosolized bacteria, and develop a mouse model of pulmonary infection to advance research in inhaled infections. The Rodent ABSLs Core will serve as a critical regional resource for collaborative pathogenesis, vaccine and diagnostic studies.