Rodent Animal Biosafety Level 3 (ABSL3)

啮齿动物生物安全等级3(ABSLS)核心的目的是为调查人员提供 有机会通过充分利用生物恐怖主义和新出现的传染病 可操作的啮齿动物设施。小动物模型在传染性疾病的研究中发挥了关键作用。 对人类很重要的疾病。特别是，啮齿动物模型已成功地用于开发和 测试疫苗和其他预防策略，以评估治疗剂的有效性和毒性，以 发展诊断学，探索发病机制。加州大学欧文分校的啮齿动物ABSLS核心包括一个状态- 先进的、完全认证的ABSLS设施为调查人员提供资源，以进行A、B类研究 和C类病原体，包括那些被指定为选择病原体的病原体。虽然主要是为小动物设计的 在工作中，ABSL3被组织起来，以便也可以容纳与选定代理的非动物工作。 通过充电程序，将向学术界和工业界的研究人员提供使用该设施的机会 在整个第九区域及以后地区；一个委员会和一个为潜在客户分配临时空间的程序 已经开发了用户。此外，设立该实验室不仅是为了提供空间，还为了提供培训， 专责内部人员进行由首席调查人员设计和监督的实验 加州大学欧文分校或其他机构。该设施将提供进行气溶胶挑战研究的机会 NIAID A、B或C类优先病原体和新出现的传染病，以便调查 并开发疫苗和吸入性生物的快速诊断测试。啮齿动物 ABSLS Core致力于实现两个具体目标：i)维护基础设施以确保可用性 为学术界和工业界的研究人员使用的地区性反弹道导弹设施。核心将保持一个 用于设施使用和技术支持的空间分配和充值单元的流程；2)建立和 在ABSLS设施中维护一个小型动物气溶胶挑战单元。将进行实验，以 验证该装置，表征气雾化细菌的生物物理性质，并开发一种小鼠模型 肺部感染以推进吸入性感染的研究。啮齿动物ABSLS核心将成为关键 协作发病机制、疫苗和诊断研究的区域资源。

The purpose of the Rodent Animal Biosafety Level 3 (ABSLs) Core is to provide investigators with the opportunity to advance research in bioterrorism and emerging infectious diseases through the use of a fully operational rodent facility. Small animal models have played a critical role in investigations of infectious diseases of importance to humans. In particular, rodent models have been successfully used to develop and test vaccines and other prevention strategies, to evaluate the efficacy and toxicity of therapeutic agents, to develop diagnostics, and to explore pathogenesis. The Rodent ABSLs Core at UC Irvine consists of a stateof- the-art, fully certified ABSLs facility offering investigators resources to conduct research on Category A, B and C pathogens, including those designated as select agents. Although designed primarily for small animal work, the ABSL3 is organized so that non-animal work with select agents can also be accommodated. Through a recharge procedure, use of the facility will be offered to investigators in academia and in industry throughout region IX and beyond; a committee and a process for allocating temporary space to potential users has been developed. Moreover, the laboratory is set up to provide not only space but also trained, dedicated in-house personnel to conduct experiments designed and supervised by Principal Investigators at UC Irvine or other institutions. The facility will offer the opportunity to conduct aerosol challenge studies of NIAID category A, B, or C priority pathogens and emerging infectious diseases in order to investigate pathogenic mechanisms and develop vaccines and rapid diagnostic tests of inhaled organisms. The Rodent ABSLs Core sets out to accomplish two specific aims: i) Maintain an infrastructure to ensure the availability of a regional ABSLs facility for use by investigators in academia and industry. The Core will maintain a process for space allocation and a recharge unit for facility use and for technical support; 2) Establish and maintain a small animal aerosol challenge unit in the ABSLs facility. Experiments will be conducted to validate the unit, characterize biophysical properties of aerosolized bacteria, and develop a mouse model of pulmonary infection to advance research in inhaled infections. The Rodent ABSLs Core will serve as a critical regional resource for collaborative pathogenesis, vaccine and diagnostic studies.