PROSPECTIVE HUNTINGTON AT RISK OBSERVATIONAL STUDY (PHAROS)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 纵向跟踪一组有亨廷顿病（HD）风险的个体，（1）确定在研究期间有多少个体出现疾病体征，（2）确定疾病的最早体征和开始的年龄，（3）检查当前用于检测HD发作的临床测量的准确性，（4）确定可能的因素，例如影响发病年龄的潜在环境因素和个人信念和态度，以及预测明显HD发病的临床前兆，和（5）检查DNA和RNA损伤标志物作为HD的潜在状态生物标志物的特异性和敏感性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To follow a group of individuals at risk for Huntington's Disease (HD) longitudinally (1) to establish how many individuals develop signs of the disease over the study period, (2) to identify the earliest signs of the illness and the age at which they begin, (3) to examine the accuracy of current clinical measures used in detecting the onset of HD, (4) to ascertain possible factors such as potential environmental modifiers and personal beliefs and attitudes influencing age of onset and clinical precursors predictive of onset of manifest HD, and (5) to examine the specificity and sensitivity of markers of DNA and RNA damage as potential state biomarkers for HD.