POSTMORTEM HUMAN BRAIN COLLECTION CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管现代脑成像在活着的患者身上有好处，精神疾病的动物模型也很多，但对实际脑组织的死后分析总是有很大的需求。对死后组织的研究可以集中在单个神经元及其辅助细胞--神经胶质细胞上，以评估细胞解剖特征、蛋白质表达以及与其他单个神经细胞突起的相互作用，这些信息是活体患者或动物模型无法获得的。 CPN人脑收藏核心由核心领导者克雷格·A·斯托克迈尔博士指导。斯托克迈尔博士在开发和管理国内领先的专门用于精神神经科学的死后人脑收藏方面拥有丰富的经验。人脑收藏从2007年到2007年由国家精神卫生研究所资助，从2007年到2012年由国家研究开发研究院资助。 大脑收集是与俄亥俄州克利夫兰的凯斯西储大学精神病学和心理学系以及俄亥俄州克利夫兰的凯霍加县验尸官办公室合作进行的。精神病学评估团队包括博士詹姆斯·C·奥沃霍尔瑟(James C.Overholser)和医学博士乔治·J·尤尔胡斯(George J.Jurjus)。奥沃霍尔瑟博士是一名临床心理学家，长期以来一直对青少年和成年人的抑郁障碍感兴趣。Jurjus博士是克利夫兰韦德公园退伍军人医院住院精神病学和戒毒科主任，自1997年以来一直是回顾性诊断小组的成员，并提供精神活性物质使用障碍方面的额外专业知识。 斯托克迈尔博士和他的合作者组织了大脑采集的方方面面，包括组织样本的存储和伴随的临床信息。CPN项目首席调查人员将获得符合纳入标准的高质量死后人脑样本，以满足他们涉及精神疾病的研究目的，以及脑组织的关键支持信息。斯托克迈尔博士进一步建议CPN调查人员为他们的生物学研究选择和匹配适当的对照和精神病学对象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the benefits of modern brain imaging in living patients and the numerous animal models of psychiatric illness, there will always be a significant need for the analysis of actual brain tissue postmortem. Studies on postmortem tissues can zero in on individual neurons and their helper cells, neuroglia, to assess cellular anatomic features, protein expression and interactions with processes from other individual nerve cells revealing information not attainable from living patients or animal models. The CPN Human Brain Collection Core is directed by Dr. Craig A. Stockmeier, Core Leader. Dr. Stockmeier has extensive experience in the development and management of one of the leading postmortem human brain collections in the country devoted specifically to psychiatric neuroscience.The Human Brain Collection was funded by the National Institute of Mental Health from 1989 through 2007 and is funded by NCRR from 2007 through 2012. The brain collection is run in collaboration with the Departments of Psychiatry and Psychology, Case Western Reserve University, Cleveland, Ohio, and with the Cuyahoga County Coroner Office, Cleveland, Ohio. The psychiatric assessment team includes James C. Overholser, Ph.D. and George J. Jurjus, M.D. Dr. Overholser, a clinical psychologist, has a long-standing career interest in depressive disorders in adolescents and adults. Dr. Jurjus, Director of Inpatient Psychiatry and Detoxification at the Cleveland Wade Park VA Hospital, has been part of the retrospective diagnostic team since 1997 and provides additional expertise in psychoactive substance use disorders. Dr. Stockmeier and his collaborators organize all aspects of the brain collection, including storage of tissue samples and accompanying clinical information. CPN Project Principal Investigators are provided with high-quality postmortem human brain samples meeting inclusion criteria for their research aims involving psychiatric illnesses, as well as the critical supporting information for the brain tissue. Dr. Stockmeier further advises CPN investigators in the selection and matching of appropriate control and psychiatric subjects for their biological studies.