SC COBRE: ANIMAL PATHOBIOLOGY CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 动物病理生物学核心的总体目标是为脂质组学和病理生物学研究人员提供利用动物模型执行其拟议研究项目的能力，并建立新的动物模型来研究疾病的发病机制。该中心将利用两种动物模型--小鼠和大鼠--来执行研究项目。虽然动物模型的使用为研究体内调节机制提供了宝贵的试剂来源，但在生理调节系统中，在生物医学研究中使用动物在设备、动物资源和技术专业知识方面是昂贵的。动物核心中心将作为执行和培训使用中心所需的所有动物操作的资源。动物核心中心将通过整合设备、专业知识和动物资源，将在中心研究计划中使用动物模型的成本降至最低。这将确保以最低成本有效地使用动物研究，并减少可能影响项目之间数据分析的变量。该提案的总体目标是：具体目标1：确保有效规划、购买和利用实验动物，包括转基因和基因改变的小鼠，保持所有动物的库存，并为科布雷调查人员繁育动物。此外，Cobre研究人员还需要产生转基因和基因改变的动物，以实现项目目标，并为R01提交文件生成初步数据。具体目标2：为支持研究项目提供必要的设施和教职员工的专业知识。该中心将在神经变性、心血管疾病、癌症和炎症的动物模型方面提供资源、培训和指导。具体目标3：提供在神经退行性变、炎症、心血管疾病和癌症病理生物学方面具有最新熟练程度的小鼠病理学专业知识。PI和共同PI都在病理学领域拥有广泛的专业知识，以提供必要的基础设施。具体目标4：维持一个数据库，其中将包括监测和跟踪所有项目动物。动物标签芯片将唯一地识别动物，核心将在尸检时将所有动物健康和最终病理评估输入数据库。这些努力将为研究提供便利，并为培养年轻教师和建立研究中心提供专业知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of the Animal Pathobiology Core is to provide the SC COBRE in Lipidomics and Pathobiology investigators with the ability to utilize animal models in the execution of their proposed research projects as well as establish new animal models for the investigation of the mechanisms involved in the pathogenesis of disease. The Center will utilize two animal models, mice and rats, in the execution of the research projects. Although the use of animal models provides an invaluable source of reagents for investigating regulatory mechanisms in vivo, in a physiologically regulated system, the use of animals in biomedical research is costly with respect to equipment, animal resources and technical expertise. The Animal Core will serve as a resource for the execution and training in the use of all animal manipulations needed in the center. The Animal Core will minimize the cost of utilizing animal models in the Center research program by consolidating the equipment, expertise and animal resources. This will ensure an efficient use of animal research at minimal cost and reduce variables that could compromise data analysis between projects. The overall aims of the proposal are: Specific Aim 1: To ensure the efficient planning, purchase and utilization of experimental animals including transgenic and gene-altered mice, to maintain stocks of all animals and to breed animals for the COBRE investigators. In addition, to generate transgenic and gene-altered animals needed by the COBRE investigators to carry out the aims of the projects and to generate preliminary data for R01 submissions. Specific Aim 2: To provide the necessary facilities and faculty and staff expertise to support the research projects. The Core will provide resources, training and mentoring in animal models of neurodegeneration, cardiovascular disease, cancer and inflammation. Specific Aim 3: To provide expertise in mouse pathology with up-to-date proficiency in neurodegenerative, inflammatory, cardiovascular disease and cancer pathobiology. Both PI and co-PI have extensive expertise in the area of pathology to provide the necessary infrastructure. Specific Aim 4: To maintain a database that will include monitoring and tracking of all project animals. Animals will be uniquely identified with animal tagging chips and the Core will input all animal health and final pathological evaluations at necropsy into the database. These efforts will facilitate the research and provide the expertise to develop young faculty and establish research centers.