NOVEL IONOPHORIC MACROMOLECULES AND POTENTIAL FUNGICIDES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项工作将涉及生产新的生物活性分子，特别是我们将集中在设计具有抗微生物和抗真菌特性的化合物。 该有机合成研究将集中在从1，3 以腈氧化物或亚硝基硅烷酸盐作为中间体进行偶极环加成反应。 拟议中的抗微生物项目将涉及将这些较小的单元连接在一起以形成可以作为离子载体的大环的挑战。 抗真菌项目将涉及一类新型化合物的合成研究。预期将非常容易改变这些潜在聚酯大分子和异恶唑杀真菌剂中的许多变量。 例如，可以通过改变四氢呋喃环的3，4-取代基的对称性来检查大环的对称性。 大环化的官能度可以从聚酯到聚醚再到聚酰胺。 因此，有许多变量，可以利用生产一系列的大环与金属阳离子的优良结合。 这个研究项目将是一个很好的机会，为许多学生感兴趣的化学和生物学背后的生物医学研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work would involve the production of novel biologically active molecules, in particular we would center on compounds designed to have anti-microbial and anti-fungal properties. This organic synthetic research would center on the production of heterocycles from 1,3 dipolar cycloadditions with nitrile oxides or nitrosilonates as intermediates. The proposed anti-microbial project would involve the challenge of attaching these smaller units together to form a macrocycle that could function as an ionophore. The anti-fungal project would involve an investigation into the synthesis of a novel class of compounds. It is expected that it will be very easy to change a number of variables in these potential polyester macromolecules and isoxazole fungicides. For example the symmetry of the macrocycle could be examined by altering the symmetry of the 3,4-substituents of the tetrahydrofuran ring. The functionality of the macrocyclization could be changed from polyester to polyether to polyamide. Thus there are many variables that could be exploited to produce a series of macrocycles with excellent bindings of metal cations. This research project would be an excellent opportunity for many students interested in both the chemistry and biology behind biomedical research.