SD SIGNAL TRANSDUCTION CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该实验室将研究调节细胞生长和分化、细胞死亡、对压力的反应和维持恒定生理条件的途径。其目标是了解细胞中可能发生的异常，这可能导致改进对一系列严重心脏和癌症疾病的检测和治疗。充血性心力衰竭的心腔扩张是由于心肌细胞形状的不适应性改变。正在进行的工作是研究与心力衰竭进展中的细胞重塑相关的分子信号。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The lab will examine the pathways that regulate cell growth and differentiation, cell death, response to stress and the maintenance of constant physiological conditions. The goal is to understand the abnormalities that can occur in cells, which could lead to improved detection and treatment of a range of serious heart and cancer conditions. Chamber dilation in congestive heart failure is due to a maladaptive change in cardiac myocyte shape. Ongoing work is investigating the molecular signaling related to cellular remodeling in the progression of heart failure.