GLUTAMATERGIC PATHWAYS IN CHILDREN WITH AND AT RISK FOR DEVELOPING MANIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：我们旨在比较双相情感障碍儿童和健康对照儿童的谷氨酸能代谢产物的浓度，以检验双相情感障碍儿童和躁狂症发作前的儿童前额叶谷氨酸浓度是否降低。 方法：用质子磁共振波谱(1H-MRS)对918岁有双相障碍家族史的儿童青少年(22例有躁狂史，BD，15例有亚综合征症状，SS)和17例健康对照(HC)进行3T质子磁共振波谱(1H-MRS)检查，研究其前扣带回(ACC)体素中谷氨酸的浓度。 数据处理采用LC模型(Provencher，2001)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: We aimed to compare concentrations of glutamatergic metabolites in bipolar offspring and healthy controls to examine whether decreases in prefrontal glutamate concentrations occur in bipolar offspringand prior to the onset of mania. Methods: 918 year old children and adolescents with a familial risk for bipolar I or II disorder (22 offspring with established history of mania,"BD," and 15 with subsyndromal symptoms without mania, "SS"), and 17 healthy controls ("HC") were examined using proton magnetic resonance spectroscopy (1H-MRS) at 3T to study glutamatergic concentrations in an 8 cc (2 x 2 x 2 cm) anterior cingulate cortex (ACC) voxel. Data was processed using LCModel (Provencher, 2001).