Botanicals and Metabolic Syndrome

描述(申请人提供)：本申请是为了续签我们的植物性膳食补充剂研究中心。我们的植物研究中心是路易斯安那州立大学(LSU)系统的彭宁顿生物医学研究中心和罗格斯大学农业和环境生物技术中心的合作成果。该中心的主题是“植物与代谢综合症”。“代谢综合征”指的是一种以肥胖、胰岛素抵抗、2型糖尿病和加速心血管疾病为主要特征的人类疾病。随着代谢综合征在世界范围内的流行，代谢综合征一直是并将继续是社会面临的最重要的公共卫生问题之一。我们的植物研究中心将包括三(3)个研究项目，一个综合生物学核心，一个植物学核心和一个行政核心。每个研究项目都将评估特定的植物药物，并评估对细胞机制的影响，这些机制被认为有助于代谢综合征的病理生理学和发展。项目1调查人员将进行研究，以评估蒿属植物部分提取物的作用机制。在动物和早期人类研究中调节胰岛素受体信号和胰岛素敏感性。项目2的调查人员将重点研究选择蒿属植物的机制。金丝桃提取物和贯叶连翘影响脂肪细胞发育、脂肪因子和胰岛素作用。项目3研究人员将评估Asclepias如何调节控制食欲和能量消耗的中央机制，以此作为改善整体能量平衡和体重的一种手段。我们建议使用尖端技术，包括新陈代谢图谱、蛋白质组评估和生物可获得性测定。因此，我们中心的科学目标是对有关分子、细胞和生理机制的特定的、令人信服的假说进行全面评估，通过这些假说，植物药可以调节代谢综合征潜在的病理生理机制的发展，并减缓代谢综合征的发展。 公共卫生相关性：考虑到代谢综合征的并发症，我们必须实施有效的策略来改善导致这种情况的潜在病理生理因素。我们对植物及其调节导致代谢综合征发展的病理过程的影响的综合研究，具有极大的潜力转化为对人类健康的实际好处。

DESCRIPTION (provided by applicant): This application is for a renewal of our Dietary Supplement Research Center focusing on Botanicals. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Biotechnology Center for Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. As the prevalence of metabolic syndrome is reaching epidemic proportions worldwide, metabolic syndrome has been, and will continue to be, one of the most important public health problems facing society. Our Botanical Research Center will consist of three (3) research projects, an Integrative Biology Core, a Botanical core and an Administrative core. Each of the research projects will evaluate specific botanicals and assess the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. Project 1 investigators will conduct studies to evaluate mechanisms of action by which selected extracts of Artemisia sp. modulate insulin receptor signaling and insulin sensitivity in both animal and in early phase human studies. Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action. Project 3 investigators will evaluate how Asclepias incarnata modulates central mechanisms controlling appetite and energy expenditure as a means to improve overall energy balance and weight. We propose to use cutting-edge technologies that include metabolomic profiling, proteomic assessments, and bioaccessibility determinations. Thus, the scientific goal of our Center is to provide a comprehensive evaluation of specific, compelling hypotheses about the molecular, cellular and physiological mechanisms by which botanicals can modulate the development of the underlying pathophysiologic mechanisms of, and attenuate the development to, metabolic syndrome. PUBLIC HEALTH RELEVANCE: Given the complications for metabolic syndrome, it is imperative that we implement effective strategies to improve the underlying pathophysiologic factors contributing to the condition. Our comprehensive study of botanicals and their effects to modulate pathologic processes leading to the development of the metabolic syndrome has great potential for being translated into practical benefits for human health.