DYNAMICS AND CEREBRAL SOURCES OF ATTENTIONAL PROCESSES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们认为注意力是一个结构，它包括三个相互关联的动态过程：1）重新定向注意力的过程，2）根据注意力的焦点有选择地处理信息的过程，3）维持注意力焦点的过程。由于这些过程的动态性质，研究潜在的大脑机制需要分析活跃的大脑区域及其时间激活模式。通过我们在前一个资助期的进展和合作项目，我们有能力获得脑电图（EEG），脑磁图（MEG），脑解剖磁共振图像（MRI）和功能性MRI（fMRI）;以及在我们的实验室整合和分析这些多模态数据的能力。这使我们能够改进我们的方法，用于EEG和MEG的大脑源的电磁源估计（EMSE），包括这些大脑区域中的时间激活模式的表征。我们现在有能力用解剖MRI来限制EMSE，并在同一受试者中用fMRI数据来告知可能的大脑来源的位置。fMRI也是一种独立的功能性神经成像方法，用于探索与注意力相关的大脑系统。拟议的项目采用这种综合的多学科方法来检查这些注意力过程中所涉及的大脑区域的空间分布和所涉及的大脑系统的时间动态特性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We consider attention to be a construct which includes three interrelated classes of dynamic precesses: 1) those involved in redirecting attention, 2) those which selectively process information according to the focus of attention, and 3) those which are involved in sustaining the focus of attention. Due to the dynamic nature of these processes, investigation of the underlying brain mechanisms requires analyses of the active brain regions and their temporal activation patterns. Through our progress in the preceding grant period and through collaborative projects, we have the ability to acquire electroencephalography (EEG), magnetoencephalography (MEG), brain anatomical magnetic resonance images (MRI) and functional MRI (fMRI); as well as the capability to integrate and analyze these multi-modal data in our laboratory. This has enabled us to improve our methods for electromagnetic source estimation (EMSE) of the brain sources of EEG and MEG, including characterization of the temporal activation patterns in these brain areas. We now have the ability to constrain the EMSE with anatomical MRI and to inform the locations of likely brain sources with fMRI data in the same subjects. fMRI also serves as a stand-alone functional neuroimaging method for exploring the brain systems involved in attention. The proposed project applies this integrated multidisciplinary approach to examination of the spatial distribution of brain areas involved in these attentional processes and characterization of the temporal dynamics of the brain systems involved.