HYPERPOLARIZED 3HE MR-LUNG CANCER LESIONS TAGGED BY TARGETED SPIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 沃伦集团与路易斯安那州立大学的卡罗拉·勒施纳长期合作，开发针对癌症的超顺磁性氧化铁纳米颗粒(SPION)。一个特别的兴趣是开发针对转移性肺癌的SPIONS。这一点已经通过组织学技术得以实现和证明。随后的目标是在活体内成像这种转移的存在。这是一个具有挑战性的目标，因为SPIONS的主要对比度是减少T2*，但肺质子已经有非常短的T2*，因此无法观察到这种效果。然而，使用3He磁共振可以缓解这个问题，因为3He有15毫秒的T2*&gt；，因此留下了足够的动态范围来观察目标转移区域的T2*减少。 我们在这个试点项目中的具体目标是进行初步的可行性研究，以测试3He MRI是否可以用于检测Warren小组提供的小鼠模型中的肺癌转移。如果我们成功地获得了这一初步的活体数据，它将被转化为拨款申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Warren Group has a long-term collaboration with Carola Leuschner of Louisiana State University to develop super paramagnetic iron oxide nanoparticles (SPIONs) to target cancer. A specific interest is to develop SPIONS that target metastatic lung cancer. This has been achieved and demonstrated by histologic techniques. A subsequent goal is to image the presence of such metasteses in vivo. This is a challenging goal because the primary contrast from SPIONS is to reduce T2*, but lung protons already have very short T2* rendering this effect unobservable. However, this problem is mitigated by using 3He MRI since 3He has a T2* > 15 ms, therefore leaving ample dynamic range for observing T2* reduction in areas of targetted metasteses. Our specific aims in this pilot project are to perform a preliminary feasibility study to test whether 3He MRI can be used to detect lung cancer metastases in mouse models supplied by the Warren group. If we are successful in obtaining this preliminary in vivo data, it would be translated into a grant application.