CLINICAL IMPLEMENTATION OF 3D RADIAL IMAGING AND RECONSTRUCTION PIPELINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 核心B的特定目标3 CIVM在动物身上生成高质量的129Xe磁共振图像的历史努力导致了这项技术向临床领域的转化。现在已经有了在受试者身上进行超极化129Xe磁共振成像的临床基础设施。该基础设施使用GE 1.5T扫描仪，运行版本为14M5，目前正在使用多层梯度回波方法对人体通风进行成像。 然而，利用超极化129Xe MRI最重要的特性的一个关键目的是直接成像进入肺血流的129Xe。这种方法首先由CIVM在(B.Driehuys，G.P.Cofer，J.Pollaro等人，Proc.娜塔莉。阿卡德。SCI。美国第103,18278(2006年))。现在至关重要的是将这种方法转化为临床环境。这是我们P41拨款的核心2的一个具体目标，在该领域被普遍认为是实现超极化129Xe磁共振成像全部临床潜力的最重要的剩余技术步骤。 对溶解在肺血中的129Xe进行成像所需的核心步骤是在临床扫描仪上进行放射状成像。径向成像以其超短的回波时间是肺组织中溶解的129Xe短T2*信号成像的关键。 本项目建议利用CIVM的基础设施和人才，在目前进行临床129Xe成像的放射肿瘤科的临床1.5T扫描仪上建立具有多核能力的3D放射状成像。除了建立成像序列外，该项目还试图建立一个强大的管道来进行数据重建。因此，它将在很大程度上利用加里·科弗(Gary Cofer)的脉冲序列和萨利·格沃特(Sally Gewalt)的专业知识和才华进行重建。我们可能需要露西·厄普丘奇的帮助来管理必要的IT基础设施，以支持重建管道。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIM 3 of CORE B Historical efforts by the CIVM to generate high-quality 129Xe MR images in animals have resulted in translation of this technology to the clinical arena. There now exists a clinical infrastructure for doing hyperpolarized 129Xe MRI in human subjects. This infrastructure uses a GE 1.5T scanner running at revision 14M5 and is currently imaging human ventilation using a multi slice gradient echo method. However, a critical aim in exploiting the most important properties of hyperpolarized 129Xe MRI is to directly image the 129Xe that enters in to the pulmonary blood stream. Such a method was first demonstrated by the CIVM in (B. Driehuys, G. P. Cofer, J. Pollaro et al., Proc. Natl. Acad. Sci. U. S. A. 103, 18278 (2006)). It is now critically important to translate this method to the clinical setting. This is a specific aim our Core 2 of our P41 grant and is generally regarded in the field as the most important remaining technical step to realizing the full clinical potential of hyperpolarized 129Xe MRI. The core step needed to image 129Xe dissolved in pulmonary blood is to implement radial imaging on the clinical scanner. Radial imaging with its ultra short echo time is the key to imaging the short T2* signal of dissolved 129Xe in pulmonary tissues. This project proposes to use the infrastructure and talents of the CIVM to establish 3D radial imaging, with multi-nuclear capability on the clinial 1.5T scanner in the department of radiation oncology where current clinical 129Xe imaging is taking place. In addition to establishing the imaging sequence, this project also seeks to establish a robust pipeline for carrying out the reconstruction of the data. It will hence draw heavily on the expertise and talents of Gary Cofer for the pulse sequences and Sally Gewalt for the reconstruction. We will likely need the help of Lucy Upchurch to manage the necessary IT infrastructure that backs the reconstruction pipeline.