DETECTION OF MALARIA INFECTION IN ERYTHROCYTES BY RAMAN MICRO-SPECTROSCOPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 疟疾仍然是最大的公共卫生问题之一，每年在世界上造成近300万人死亡，主要是在撒哈拉以南非洲。在缺乏真正有效的疟疾疫苗的情况下，至关重要的是优先开展早期检测工作，特别是如果这种高度敏感的方法能够以非侵入性方式实施的话。鉴于近红外(NIR)拉曼光谱在经皮检测包括葡萄糖、肌酐和尿素在内的血液分析方面的良好记录，它可能提供一种在体内探测疟疾的极佳工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Malaria remains one of the largest public health problems accounting for nearly three million deaths a year in the world, primarily in sub-Saharan Africa. In the absence of a truly effective malarial vaccine, it is critical that early stage detection efforts are prioritized  especially if such a highly sensitive method can be implemented non-invasively. Near infrared (NIR) Raman spectroscopy potentially provides an excellent tool to probe malaria in vivo, given its promising track record in transcutaneous detection of blood analytes including glucose, creatinine and urea.