GAMMA SYNUCLEIN AGGREGATES AND GLAUCOMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 青光眼是一种神经退行性疾病，会杀死视网膜神经节细胞，是全球第二大致盲原因。我们最近在多种青光眼动物模型中的数据表明，这种疾病的特征是伽玛突触核蛋白(Sncg)的病理形式类似于帕金森病中的α突触核蛋白。为了揭示这些Sncg形式的本质，我们提出了对青光眼小鼠模型DBA/2J小鼠的视神经头以及在视网膜神经节细胞中过表达标签-Sncg的转基因青蛙的轴突和终末进行的电子和免疫电子显微镜分析。通过展示青光眼和帕金森病的常见细胞病理学，目前的研究将对这两种同样常见的神经退行性疾病的当前研究和未来治疗产生很大影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glaucoma is a neurodegenerative disorder that kills retinal ganglion cells and is the second leading cause of blindness worldwide. Our recent data in multiple animal models of glaucoma suggest that this disease is characterized by pathological forms of gamma synuclein (Sncg) that resemble those seen for alpha synuclein in Parkinson's disease. In order to uncover the nature of these Sncg forms, we propose electron and immunoelectron microscopy analyses of the optic nerve head in a mouse model of glaucoma, the DBA/2J mouse, and of axons and terminals of transgenic frogs that overexpress tagged-Sncg in retinal ganglion cells. By demonstrating common cellular pathology in glaucoma and Parkinson's disease, the current studies stand to have a large impact on the current study and future treatment of these two equally common neurodegenerative disorders.