DEVELOPMENT AND DEPLOYMENT OF FLEXIBLE AND SCALABLE CI FOR BIOMED RESEARCH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目标 我们在这一核心的目标是解决在药物发现、细胞和器官建模以及基于当前和新兴的计算、数据和网络基础设施的图像重建中调整、优化和配置生物医学应用的实际问题。同时，我们必须确保开展多尺度分析所需的大型成套软件的可及性、可重复性和多功能性。 具体目标 目标1：扩展和调整多尺度生物学代码以适应高性能集群和多核处理器：允许应用程序代码利用新的“机器平衡”，其中单个节点成为大规模、共享内存的对称多处理器(SMP)。 AIM2：提供对多尺度和多物理的透明和基于服务的访问 生物医学代码：尽可能多地隐藏复杂性，可以让科学家更容易地对开展研究所需的系统或工作流程的逻辑进行推理，而不是对低级别的系统细节进行推理。 目标3：定义、测试和支持完整的网络基础设施：通过了解外部提供的软件，将其组装成一个基于标准Linux操作系统的发行版，并定期严格地进行测试，从而提供一个可重现的网络环境。 目标4：整合和交付翻译研究的工具：整合和 测试选定的软件应用程序流水线的“套件”

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives Our objective in this core is to address the practical issues of adapting, optimizing and provisioning biomedical applications in drug discovery, cellular and organ modeling, and image reconstruction based upon current and emerging computing, data and network infrastructures. At the same time, we must ensure the accessibility, reproducibility and versatility of the large ensembles of software that are required to carry out multiscale analysis. Specific Aims Aim 1: Scaling and Adapting Multiscale Biology Codes to High-Performance Clusters and Multicore Processors: To allow application codes to take advantage of a new "balance of machines where individual nodes become large-scale, shared-memory symmetric multiprocessors (SMPs). Aim2: Providing Transparent and Service-Based Access to Multiscale and Multiphysics Biomedical Codes: To hide as much complexity as possible allows scientists to reason more easily about the logic of the systems or workflows required to carry out their research  and less about the low-level system details. Aim 3: Defining, Testing, and Supporting a Complete Cyberinfrastructure: To provide a reproducible cyberenvironment by understanding externally-supplied software, assembling into a distribution that sits on top of a standard Linux operating system, and regularly and rigorously testing. Aim 4: Integrating and Delivering Tools for Translational Research: To integrate and test selected "suites" of software application pipelines