SEX DIFFERENCES IN THE ABUSE-RELATED EFFECTS OF BENZODIAZEPINES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 安定和相关药物，被称为“苯二氮卓类”，被广泛用于治疗焦虑和睡眠障碍，这是美国最常见的两种精神疾病。苯二氮卓类被认为是现代医学中最安全的处方药之一，但不幸的是，它们也是滥用药物，女性的患病率高于男性。 本次修订的目的是揭示苯二氮卓类药物滥用潜力的性别差异，总体目标是开发更安全的药物来治疗焦虑和睡眠障碍，无论性别如何。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Valium and related drugs, referred to as "benzodiazepines" are prescribed widely for the treatment of anxiety and sleep disorders, two of the most common psychiatric disorders in the U.S. Benzodiazepines are considered to be among the safest prescription drugs in modern medicine, but they unfortunately are also drugs of abuse, with higher prevalence in women than men. The aim of this revision to our parent grant is to uncover sex differences in the abuse potential of benzodiazepines, with the overall goal of developing safer drugs for treating anxiety and sleep disorders regardless of gender.