HEART DYSAUTONOMIA IN PARKINSON'S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：建立神经毒素6-羟基多巴胺诱导的自主神经功能障碍的检测方法。 PD与自主神经支配的丧失有关。心脏是受影响的关键器官之一。因此，PD患者存在心脏自主神经功能障碍症状，如自主性低血压或心律失常。目前，还没有很好地表征这些问题的非人灵长类动物模型。通过由PD专家，心脏病专家和成像专家组成的跨学科团队，我们正在开发一系列测试，以评估神经毒素6羟基多巴胺全身给药引起的自主神经功能障碍。 该项目的初步结果表明，静脉注射6-OHDA可诱导支配心脏的儿茶酚胺能神经元的神经变性，并可用于模拟PD患者的心脏自主神经功能障碍。 本研究使用WNPRC Assay Services和CPI。 正在编写一份出版物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To develop tests to access autonomic dysfunction induced by systemic administration of the neurotoxin 6 hydroxydopamine. PD is associated with loss of autonomic innervation. The heart is one key organ affected. As such, PD patients present heart dysautonomia symptoms like autostatic hypotension or arrhythmias. Currently, there are not well characterized nonhuman primate models of these problems. Through an interdisciplinary team consisting of PD experts, cardiologists and imaging experts, we are developing a battery of tests to access autonomic dysfunction induced by systemic administration of the neurotoxin 6 hydroxydopamine. Preliminary results from this project suggest that intravenous administration of 6-OHDA induces neurodegeneration of catecholaminergic neurons innervating the heart and can be used to model heart autonomic dysfunction in PD. This research uses WNPRC Assay Services and CPI. A publication is in preparation.