NEUROLOGICAL DEFICIT AS A RESULT OF TENSION-EXTENSION OF THE CERVICAL SPINE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在成功实现神经组织再生之前，预防脊髓损伤（SCI）对于减轻其后遗症至关重要。 目前，超过250，000名患有SCI的美国人必须忍受其使人衰弱的后果，通过现有的医学治疗几乎没有改善的希望。 虽然对神经再生和修复的研究工作正在进行中，但损伤预防提供了一种避免SCI的方法，这种方法总是比治疗更可取。 预防SCI的关键之一是了解人类耐受性的极限（即，暴露极限）对作用在脊柱上的潜在有害力的影响。 预防策略和设备依赖于这些知识，以开发有效的设计和台架测试其性能。 以前的损伤研究提供了基于脊柱结构破坏的暴露限值，但这些限值并不能指示神经组织是否已受损。 由于SCI可能在没有脊柱结构破坏的情况下发生，因此本研究旨在研究神经损伤的阈值（发病），以帮助确定更保守的暴露限值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Until the regeneration of neural tissues is successfully achieved, the prevention of spinal cord injury (SCI) is paramount in mitigating its sequelae. Currently, over 250,000 Americans with SCI must endure its debilitating consequences with little hope of improvement through existing medical treatment. While promising research efforts toward neuro-regeneration and repair are underway, injury prevention offers a means of avoiding SCI which will always be preferable to treatment. One of the keys to preventing SCI is in understanding the limits of human tolerance (i.e., exposure limits) to potential injurious forces acting on the spine. Prevention strategies and devices depend on this knowledge in order to develop effective designs and bench test their performance. Previous injury research has provided exposure limits based on structural failure of the spinal column, but these limits do not provide an indication of the whether the neurologic tissues have been damaged. Because SCI may occur without structural failure of the spine, this study seeks to investigate the threshold (onset) of neurological injury to help determine more conservative exposure limits.