NEUROLOGICAL DEFICIT AS A RESULT OF TENSION-EXTENSION OF THE CERVICAL SPINE

颈椎紧张伸展导致的神经功能缺陷

• 批准号: 8357609
• 负责人: RANDAL P CHING
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357609
• 关键词: Air Bags; Animal Model; Bicycling; Brain; Car Seats; Cervical spine; Chin; Data; Devices; Ensure; Equipment; Event; Evoked Potentials; Funding; Grant; Head; Helmet; Injury; Laboratory Study; Lifting; Methods; Monitor; National Center for Research Resources; Nervous System Trauma; Neurologic; Pilot Projects; Prevention; Primates; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Safety; Science; Signal Transduction; Source; Spinal Cord; Spinal cord injury; Stretching; System; Testing; United States National Institutes of Health; Vertebral column; cost; design; functional restoration; prevent; repaired; spinal cord repair; vehicular accident

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This pilot study was designed to investigate the onset of neurological injury under tensile loading using an animal model. Although much research is being done, science has yet to develop a method for repairing the spinal cord to restore function to the neurological system. Until then, the only available alternative to repair is prevention. To prevent spinal cord injury (SCI), more data are needed to help establish safe exposure limits for the spine. The design and testing of new safety devices and equipment (such as bicycle helmets and car seats) require exposure limits so that safety devices can be properly evaluated to ensure that these limits are not exceeded. Motor vehicle accidents are one of the most common causes of SCI, and tension injuries can occur when an air bag deploys and gets caught under the chin causing the head to be lifted upwards (relative to a belted torso) or when a frontal impact causes the car and car seat to suddenly stop but the head continues moving forward (due to inertia). In these types of events, the cervical spine may stretch beyond the safe limits of the spinal cord thus resulting in a SCI. This study seeks to increase our understanding of SCI and help establish exposure limits to ultimately reduce SCI. To examine the exposure limits of the spinal cord in tension, a controlled laboratory study has been designed to monitor the neurological signals sent from the brain through the spinal cord while tension is applied to the spine (i.e., evoked potentials--EPs). An anesthetized animal model will be used to determine the amount of tension (stretch) that can be applied before the EP signals diminish indicating the onset of SCI.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项先导性研究旨在利用动物模型研究拉伸负荷下神经损伤的发生。尽管正在进行大量研究，但科学尚未开发出修复脊髓以恢复神经系统功能的方法。在此之前，唯一可用的修复选择是预防。为了预防脊髓损伤(SCI)，需要更多的数据来帮助建立脊柱的安全暴露限值。设计和测试新的安全装置和设备(如自行车头盔和汽车座椅)需要有暴露限值，这样才能对安全装置进行适当评估，以确保不超过这些限值。 机动车事故是脊髓损伤最常见的原因之一，当安全气囊展开并被卡在下巴下导致头部向上抬起(相对于系着安全带的躯干)时，或者当正面碰撞导致汽车和汽车座椅突然停止但头部继续向前移动(由于惯性)时，可能会发生张力性损伤。在这些类型的事件中，颈椎可能会超出脊髓的安全界限，从而导致脊髓损伤。 这项研究旨在增加我们对脊髓损伤的了解，并帮助建立暴露限制，最终减少脊髓损伤。为了检查脊髓在张力中的暴露限度，设计了一项对照实验室研究，以监测在对脊柱施加张力时从大脑通过脊髓发出的神经信号(即诱发电位-EPs)。麻醉动物模型将被用来确定在EP信号减弱之前可以施加的张力(拉伸)量，这表明脊髓损伤的开始。