THERAPEUTIC EFFECTS AND ABUSE OF GABA(A) MODULATORS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 苯二氮卓类药物（BZ）被广泛用作抗焦虑药、催眠药、肌肉松弛药和抗惊厥药。 虽然BZ被认为是现代医学中最安全的处方药之一，但它们的效用受到许多副作用的限制，包括不必要的镇静，运动性能受损和成瘾的责任。 该项目旨在确定GABA（A）受体亚型机制，这些机制是BZ型药物临床有益的副作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Benzodiazepines (BZs) are prescribed widely as anxiolytics, hypnotics, muscle relaxants, and anticonvulsants. Although BZs are considered to be among the safest prescription drugs in modern medicine, their utility is constrained by a number of side effects, including unwanted sedation, impaired motor performance, and the liability for addiction. This project seeks to identify the GABA(A) receptor subtype mechanisms underlying the clinically beneficial vs. unwanted side effects of BZ-type drugs.