TRANSPLANTATION OF ES CELLS-DERIVED DOPAMINERGIC NEURONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：探讨人和猴胚胎干细胞来源的多巴胺神经元在帕金森病细胞替代治疗中的应用。 细胞替代策略已被提出作为晚期帕金森氏症的治疗方法。 三年前，我们开始了一项初创资金的试点研究，使用多巴胺能人类ES细胞来评估猴子大脑的活性和安全性。两年前，我们分析了这些数据。我们的结果表明，猴子大脑中分化的HES细胞能够引发免疫反应，影响它们的多巴胺能特征和生存。 这项研究使用了动物服务、CPI、干细胞资源和病理学服务。 这个项目的启动资金已经结束；出版工作已经完成。 出版物： 神经疾病干细胞疗法的临床前评估。伊拉尔约·51：24-41。 Fitzpatrick K.，Raschke J.，Emborg M.E.(2009)帕金森氏病基于细胞的疗法：过去、现在和未来。抗氧化氧化还原信号。11：2189-208。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To explore the use of human and monkey embryonic stem (ES) cells derived dopamine neurons for cell replacement therapy in Parkinson's disease. Cell replacement strategies have been proposed as a treatment for advanced Parkinson's disease. Three years ago, we began a pilot study with start-up funding using dopaminergic-human ES cells to assess viability and safety in the monkey brain. Two years ago, we analyzed the data. Our results suggest that differentiated hES cells in the monkey brain are able to elicit an immune response that affects their dopaminergic characteristics and survival. This research used Animal Services, CPI, Stem Cell Resource, and Pathology Services. This project's start-up funding has ended; publications have resulted. PUBLICATIONS: Joers V., Emborg M.E. Preclinical assessment of stem cell therapies for neurological diseases. ILAR J. 51:24-41. Fitzpatrick K., Raschke J., Emborg M.E. (2009) Cell-based therapies for Parkinson's disease: past, present and the future. Antioxid Redox Signal. 11:2189-208.