MATERNAL AND DIETARY FACTORS ASSOCIATED WITH IRON DEFICIENCY ANEMIA IN INFANCY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：探讨铁缺乏、铁充足和铁过量的相关因素。 该项目于2009年12月启动，调查与婴儿缺铁性贫血相关的母亲和饮食因素。 一个重要的因素是饮食中的铁含量，无论是对怀孕期间的母亲还是哺乳期和护理幼儿的母亲。 目前，包括WNPRC在内的许多研究机构使用的是一种比以前喂给猴子的食物含有更多铁的商业食物。 因此，有一个令人信服的理由将根据这些数据怀孕和饲养的幼猴的血液学状态与先前存在的标准进行比较。这项正在进行的研究确定了6个月和12个月大的婴儿恒河猴的铁面板，以评估与铁缺乏，充足和过量相关的因素。 这些后代来自未经产和经产的雌性，因为年轻的第一次母亲产生铁缺乏后代的风险更高。 先前的研究已经证明，缺铁与大脑发育的许多显著影响有关， 包括对基本单胺神经递质通路的影响。 这项研究使用WNRPC动物服务。 出版物： Coe CL，Lubach GR，Bianco L，Beard JL.幼年期缺铁性贫血史改变幼年猴脑单胺活性。心理生物学发展2009年4月; 51（3）：301 - 9。PMID：19194962。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To evaluate factors associated with iron deficiency, sufficiency and excess. This project, initiated in December 2009, investigates maternal and dietary factors associated with iron deficiency anemia in infancy. One important factor is the amount of the iron in the diet, both for the mother during pregnancy and while lactating and nursing a young infant. Currently, many research facilities, including the WNPRC, use a commercial chow with more iron in it than previously fed to monkeys. Hence there was a compelling reason to compare the hematological status of infant monkeys gestated and reared on this data to preexisting norms. This ongoing study determines an iron panel on infant rhesus monkeys at 6 and 12 months age to evaluate factors associated with iron deficiency, sufficiency and excess. The offspring are from primiparous and multiparous females because younger, first time mothers are at higher risk for generating iron deficient offspring. Previous research has demonstrated that iron deficiency is associated with a number of significant effect on brain development, including on the essential monoamine neurotransmitter pathways. This research used WNRPC Animal Services. PUBLICATION: Coe CL, Lubach GR, Bianco L, Beard JL. A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys. Dev Psychobiol. 2009 Apr;51(3):301-9. PMID: 19194962.