BONE BIOLOGY CORE

骨生物学核心(核心B)的目的是提供一套标准化的骨分析服务，以促进完成计划项目目标和特定目标的更广泛的目标和反对意见。 该计划项目申请的目标是了解营养相关因素的年龄相关变化如何改变骨中干细胞的环境环境。这三个项目中的每一个都研究这些营养相关信号的不同方面，但都将使用相似的技术和动物模型。骨生物学核心将在骨组织学和组织形态计量学、成像、密度计量学、生物力学和血清生物化学领域为每位研究人员提供标准的化验服务。马克·哈姆里克博士将担任核心主任。他是一位骨生物学家，在骨组织形态计量学、密度计量学和生物力学领域拥有丰富的经验和专业知识，特别强调在骨代谢研究中使用动物模型。他将负责监督与Core B狂热有关的所有行政问题，以及监督骨标本的收集、准备和分发。核心将作为与骨骼代谢相关的数据收集的主要中心，因此是连接各个项目的关键组成部分。此外，核心寻求开发新技术，以支持未来与计划项目拨款目标相关的研究活动。

The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion ofthe broader goals and objections ofthe Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in nutrient-related factors alters the environmental milieu of stem cells in bone. Each ofthe three projects investigates different aspects ofthese nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B fadlities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.