Core B - Bone Biology Core

核心 B - 骨生物学核心

• 批准号: 9209553
• 负责人: MARK W HAMRICK
• 金额: $ 30.4万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9209553
• 关键词: Address; Age; Aging; Animal Model; Area; Biochemical Markers; Biochemistry; Biological Assay; Biology; Biomechanics; Collection; Consult; Data Collection; Densitometry; Development; Dietary Intervention; Dual-Energy X-Ray Absorptiometry; Epigenetic Process; Goals; Histology; Histone Deacetylase; Image; Impairment; Individual; Link; MicroRNAs; Nutrient; Phenotype; Preparation; Program Research Project Grants; Research; Research Activity; Research Personnel; Serum; Services; Signal Transduction; Specimen; Standardization; Stem cells; Supervision; Techniques; Technology; Testing; Time; age related; bone; bone loss; bone metabolism; bone turnover; epigenetic regulation; experience; microCT; mouse model; new technology; programs; skeletal

The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion of the broader goals and objections of the Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in the epigenetic regulation of stem cells in bone can be modified by nutrient-related factors. Each of the four projects investigates different aspects of these epigenetic- and nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B facilities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.

骨生物学核心（核心B）的目的是提供一套标准化的骨测定服务， 将有助于完成更广泛的目标和反对方案项目的目标和具体目标。 本计划项目应用程序的目的是了解如何在年龄相关的变化 骨中干细胞的表观遗传调节可以通过营养相关因子来改变。四个 项目调查这些表观遗传和营养相关信号的不同方面，但所有这些都将采用 类似的技术和动物模型。骨生物学核心将为每位研究者提供标准 在骨组织学和组织形态计量学、成像、光密度测定、生物力学、 和血清生化。Mark Hamrick博士将担任核心主任。他是一位有经验的骨骼生物学家， 在骨组织形态计量学，密度测定学和生物力学领域的专业知识，特别强调 动物模型在骨代谢研究中的应用。他将负责监督所有 与核心B设施有关的行政问题，以及监督收集、准备和 骨标本的分布。Core将作为骨相关数据收集的主要中心 新陈代谢，因此是连接各个项目的关键组成部分。此外，核心 寻求开发新技术，以支持与《联合国千年宣言》目标有关的未来研究活动。 计划项目补助金。