Core B - Bone Biology Core

骨生物学核心(核心B)的目的是提供一套标准化的骨分析服务， 将有助于完成计划项目目标和特定目标的更广泛的目标和异议。 本计划项目申请的目标是了解年龄相关的变化如何在 骨中干细胞的表观遗传调控可以被营养相关因子改变。四个人中的每一个 项目研究了这些表观遗传和营养相关信号的不同方面，但都将使用 相似的技术和动物模型。骨生物学核心将为每位研究人员提供标准 在骨组织学和组织形态计量学、成像、密度计量学、生物力学、 和血清生化。马克·哈姆里克博士将担任核心主任。他是一位有经验的骨生物学家 在骨组织形态计量学、密度计量学和生物力学领域的专业知识，特别强调 动物模型在骨代谢研究中的应用。他将负责监督所有 与核心B设施有关的行政问题，以及监督收集、准备和 骨标本的分布情况。核心将作为与骨骼相关的数据收集的主要中心 新陈代谢，因此是连接各个项目的关键组成部分。此外，核心 寻求开发新技术，以支持未来与世界银行目标相关的研究活动 计划项目拨款。

The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion of the broader goals and objections of the Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in the epigenetic regulation of stem cells in bone can be modified by nutrient-related factors. Each of the four projects investigates different aspects of these epigenetic- and nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B facilities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.