Core B - Bone Biology Core

核心 B - 骨生物学核心

• 批准号: 9902283
• 负责人: MARK W HAMRICK
• 金额: $ 29.07万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9902283
• 关键词: Address; Age; Aging; Animal Model; Area; Biochemical Markers; Biochemistry; Biological Assay; Biology; Biomechanics; Collection; Consult; Data Collection; Densitometry; Development; Dietary Intervention; Dual-Energy X-Ray Absorptiometry; Epigenetic Process; Goals; Histology; Histone Deacetylase; Image; Impairment; Individual; Link; MicroRNAs; Nutrient; Phenotype; Preparation; Program Research Project Grants; Research; Research Activity; Research Personnel; Serum; Services; Signal Transduction; Specimen; Standardization; Supervision; Techniques; Technology; Testing; Time; age related; bone; bone loss; bone metabolism; bone turnover; epigenetic regulation; experience; microCT; mouse model; new technology; programs; skeletal; stem cells

The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion of the broader goals and objections of the Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in the epigenetic regulation of stem cells in bone can be modified by nutrient-related factors. Each of the four projects investigates different aspects of these epigenetic- and nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B facilities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.

骨生物学核心（核心B）的目的是提供一组标准化的骨测定服务， 将有助于完成计划项目目标和特定目标的更广泛的目标和异议。 该计划项目应用程序的目的是了解与年龄相关的变化 骨中干细胞的表观遗传调节可以通过养分相关因素来改变。四个 项目调查了这些表观遗传和营养相关的信号的不同方面，但所有这些都将采用 类似的技术和动物模型。骨生物学核心将为每个研究者提供标准 骨组织学和组织学区域的测定服务，成像，密度计，生物力学，生物力学， 和血清生物化学。马克·哈姆里克（Mark Hamrick）博士将担任核心主任。他是一位有经验的骨骼生物学家 在骨骼组织形态法，密度计和生物力学领域的专业知识，特别强调 在骨代谢研究中使用动物模型。他将负责监督所有 与核心B设施有关的行政问题，以及监督收集，准备和 骨标本的分布。核心将作为与骨骼有关的主要数据收集中心 代谢，因此代表了连接各个项目的关键组成部分。而且，核心 试图开发新技术来支持与未来的研究活动有关 计划项目赠款。