2011 Mammalian Gametogenesis and Embryogenesis Gordon Research Conference

描述（由申请人提供）：本申请要求为将于2011年8月21日至26日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行的第18届戈登哺乳动物配子发生和胚胎发生会议提供部分资金。本次会议提供了一个独特而宝贵的机会，供致力于为患者提供最现代治疗方法的临床医生和正在研究配子发生和胚胎发生正常和异常功能的生物学机制的基础科学家之间进行讨论和交流。了解产生有活力的卵子和精子以及胚胎发育启动的分子机制对于动物物种的持续生存至关重要。生殖生物学的进展不仅可用于治疗人类不育和生育力低下，而且可用于改进避孕方法的开发、农业工程的进展和野生动物保护的新方法。此外，干细胞、多能细胞、配子和早期胚胎为基础研究提供了重要的模型，这些基础研究旨在了解表观遗传学、成人疾病的发育起源、表观基因组的环境扰动、核编程和细胞周期调控，以及转录、翻译和翻译后控制机制。这些领域对各种生物医学应用具有潜在意义。关于哺乳动物配子发生和胚胎发生的戈登会议的目标是为该领域的最新进展提供一个交流论坛，并通过提供一个促进互动的轻松环境来促进讨论和辩论。戈登会议环境的一个特别重要的方面是年轻和成熟的研究人员以及国家和国际科学家的融合，以促进交流，产生新的想法，促进新的合作。 公共卫生相关性：了解产生有活力的卵子和精子以及胚胎发育启动的分子机制对于创造有活力的健康后代至关重要。生殖生物学的进展不仅可用于治疗人类不孕不育和开发新的避孕方法，还可用于更好地了解环境对表观基因组的影响和成人疾病的发育起源。配子和早期胚胎的研究对于我们理解人类生殖健康和疾病至关重要。

DESCRIPTION (provided by applicant): This application requests partial funding for the 18th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 21-26, 2011 at Waterville Valley Resort in Waterville Valley New Hampshire. This conference provides a unique and valuable opportunity for discussion and the exchange of ideas between clinicians devoted to delivering the most modern therapeutic approaches to their patients, and basic scientists who are examining the biological mechanisms that underlie normal and abnormal function of gametogenesis and embryogenesis. Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the continued survival of animal species. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and subfertility, but also for improvements in developing contraceptive methods, advances in agricultural engineering and novel approaches to wildlife preservation. Moreover, stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding epigenetics, the developmental origins of adult disease, environmental perturbation of the epigenome, nuclear programming and cell cycle regulation, as well as transcriptional, translational, and post-translational control mechanisms. These areas have potential significance for a wide variety of biomedical applications. The objective of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction. A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators, as well as national and international scientists to promote exchanges that will generate new ideas and facilitate new collaborations. PUBLIC HEALTH RELEVANCE: Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the creation of viable healthy offspring. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and the development of new contraceptive methods, but also for a better understanding of environmental influences on the epigenome and the developmental origins of adult disease. The study of gametes and early embryos is critical to our understanding of human reproductive health and disease.