Mitochondrial Physiology and Medicine

描述（由申请人提供）： 该提案要求提供资金，以支持将于2011年9月7日至11日在马萨诸塞州伍兹霍尔的海洋生物实验室举行的“线粒体生理学和医学”国际研讨会。这次会议将是普通生理学家协会（SGP）的第65届年度研讨会。SGP的年度研讨会已经确立了其遗产，成为全球生理学家，细胞生物学家和生物药理学家的首要和最具创新性的会议，跨越所有职业阶段和专业领域。最近的突破性发现证明了线粒体在控制人类生理和疾病中的关键作用，使线粒体重新回到了生物医学研究的中心舞台。通常有200名参与者，SGP研讨会足够大，可以对重点研究领域进行详细和深入的分析，同时又足够小，可以最大限度地提高个人讨论，促进学生，博士后研究员，新研究人员和该领域内的领导者之间的合作互动。 一个令人难以置信的丰富和雄心勃勃的计划已经制定了这次会议。具体而言，会议受益于两位国际知名的线粒体研究领导者作为主旨发言人：大卫克拉彭博士（哈佛医学院）和道格拉斯华莱士博士（费城儿童医院）。该计划是由一个令人印象深刻的组织委员会开发的，该委员会由线粒体研究领域公认的领导者组成，包括P. Bernardi博士（帕多瓦大学），R。Dirksen（罗切斯特大学），R. Gottlieb（San Diego州立大学），G. HajnLczky（托马斯杰斐逊大学）和B O 'Rourke（约翰霍普金斯大学）。研讨会将集中在5个首要主题：（1）线粒体形态，运动和动力学，（2）线粒体系统生物学，（3）线粒体离子通道和转运蛋白，（4）线粒体通讯和信号传导，（5）细胞死亡和疾病中的线粒体。这些主题代表了从分子到人类水平的线粒体生理学和医学的整合，特别强调线粒体作为心血管疾病的药物和治疗靶点的作用。我们预计，本次会议将吸引大约150-200名基础和临床科学家，他们将在线粒体研究的前沿工作。普通生理学家协会和组织委员会的成员准备确保这次研讨会的成功。我们的目标是，通过公开对话和交流，新的和重要的想法和新的疗法将作为这次及时会议的直接结果出现。

DESCRIPTION (provided by applicant): This proposal requests funds to support an international symposium on "Mitochondrial Physiology and Medicine" to be held on September 7 - 11, 2011, at the Marine Biological Laboratory in Woods Hole, MA. This meeting will be the 65th Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has established its legacy as being the premier and most innovative meeting for physiologists, cell biologists, and biophysicists worldwide that span across all career stages and professional arenas. Recent groundbreaking discoveries demonstrating the pivotal role of mitochondria in controlling human physiology and disease have repositioned mitochondria back to the center stage of biomedical research. With typically d 200 participants, SGP symposia are large enough to provide detailed and in depth analyses of a focused area of research, while at the same time being small enough to maximize individual discussions and foster collaborative interactions between students, postdoctoral fellows, new investigators and established leaders within the field. An incredibly enriched and ambitious program has been developed for this meeting. Specifically, the meeting benefit greatly from two internationally-acclaimed leaders in mitochondrial research as keynote speakers: Dr. David Clapham (Harvard Medical School) and Dr. Douglas Wallace (Children's Hospital of Philadelphia). The program was developed by an impressive Organizing Committee consisting of recognized leaders in mitochondrial research including Drs. P. Bernardi (University of Padova), R. Dirksen (University of Rochester), R. Gottlieb (San Diego State University), G. HajnLczky (Thomas Jefferson University), and B O'Rourke (Johns Hopkins University). The symposium will focus on 5 overarching themes: (1) mitochondrial morphology, movement, and dynamics, (2) mitochondrial systems biology, (3) mitochondrial ion channels and transporters, (4) mitochondrial communication and signaling, and (5) mitochondria in cell death and disease. These topics represent an integration of mitochondrial physiology and medicine from molecular to human levels with a special emphasis on the role of mitochondria as agents and therapeutic targets in cardiovascular disease. We expect that this conference will attract approximately 150-200 basic and clinical scientists across all career stages working at the cutting edge of mitochondrial research. The Society of General Physiologists and the members of organization committee are poised to ensure the success of this symposium. It is our aim that through open dialogue and communication, new and important ideas and novel therapies will emerge as a direct result of this timely meeting.