2011 GRC & GRS on Cell Biology of Megakaryocytes and Platelets

描述（由申请人提供）：关于巨核细胞和血小板细胞生物学的戈登研究会议（GRC）是关注巨核细胞生物学和由此产生的血小板的首要科学会议。这将是第四次两年一次的会议，由Steve Watson和Jon Frampton于2005年首次组织，将两组具有互补目标和兴趣的科学家聚集在一起。我们的会议将从造血/巨核生成生物学开始，扩展到血小板生物发生和血小板（病理）生物学。演讲将重点介绍巨核细胞在不同发育阶段形成的最新进展，并涵盖转录、miRNA和表观遗传调控途径的新见解。接下来将介绍围绕血小板生成的生物学事件，然后是影响巨核生成和血小板生成的疾病，重点是骨髓增殖性疾病。将介绍新的受体系统和血小板细胞内通路及其对血栓形成、增殖、稳定和溶解的作用机制，以及血小板中已建立的通路以及对这些过程的新见解如何有助于我们对止血和血栓形成的理解。新的观点将通过一个专门讨论巨核生成和血小板生物学研究中最先进的基因组学和生物信息学的会议获得。最后的会议将致力于途径和细胞机制，调节血小板病理。该GRC与为期两天的戈登研究研讨会（GRS）相结合，为对该领域感兴趣的学员提供机会，让学员有机会展示他们的研究成果，并从该领域的高级学术和行业研究人员那里获得见解。最好的学员报告也将在主会议上作为3-4个青年研究者系列演讲的一部分进行介绍。将安排一次GRS和四次GRC海报会议，为初级和高级研究人员提供一个额外的论坛，以建立网络和交流思想。GRS和GRC会议分别于2011年3月19日至20日和20日至25日在位于墨西哥湾的德克萨斯州加尔维斯顿岛美丽而历史悠久的加尔维斯酒店举行。拥有独特的宽阔海滩和岛上及附近众多景点，这将是一个令人兴奋和难忘的场所，为所有与会者。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes and the platelets that arise from them. This will be the 4th biennial meeting that was first organized by Steve Watson and Jon Frampton in 2005 to bring together two groups of scientists with complimentary goals and interests. Our meeting will begin with the biology of hematopoiesis/megakaryopoiesis and extend to platelet biogenesis and platelet (patho)biology. Presentations will focus on state-of-the-art advances in the formation of megakaryocytes at various stages of development and covering new insights into transcriptional, miRNA and epigenetic regulatory pathways. This will be followed by coverage of the biological events surrounding thrombopoiesis and then disorders that affect megakaryopoiesis and thrombopoiesis, focusing on the myeloproliferative diseases. New receptor systems and intracellular pathways in platelets and mechanisms of their contribution to clot formation, propagation, stability and resolution will be presented, as will a session on established pathways in platelets and how new insights into these processes have also contributed to our understanding of hemostasis and thrombosis. New perspectives will be gained via a session devoted to state- of-the-art genomic and bioinformatics in the study of megakaryopoiesis and platelet biology. The final session will be devoted to pathways and cellular mechanisms that regulate platelet pathologies. This GRC is tied in with a two-day Gordon Research Seminar (GRS) for trainees interested in this field and will give trainees the opportunity to present their research as well as gain insights from senior academic and industry investigators in this area. The best trainee presentations will also be presented as part of a series of 3-4 Young Investigator talks at the main conference. One GRS and four GRC poster sessions will be scheduled, giving junior and senior investigators an additional forum to network and exchange ideas. The GRS and GRC meetings take place from March 19-20th and 20-25th, 2011, respectively, at the beautiful, historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees. PUBLIC HEALTH RELEVANCE: Platelets are critical for normal clotting and are a major contributor to pathologic thrombi such as those that underlie the major cardiovascular diseases, heart attacks and strokes. This application request partial support for the costs of organizing and running the 4th Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets and the 1st satellite Gordon-Kenan Research Seminar for trainees. State-of-the- art presentations and discussions of the underlying biology of platelets and the megakaryocytes that give rise to platelets will be coupled to mentoring experiences for young investigators with the overall goal of advancing new insights to improve prevention and care of cardiovascular diseases.