MMRRC Annual Meeting

描述(由申请人提供)：突变小鼠区域资源中心(MMRRC)是由美国国立卫生研究院支持的一个主要的国家突变小鼠档案和分发联盟，为生物医学研究社区提供转基因小鼠、冷冻保存材料、胚胎干细胞系、技术支持和增值服务。MMRRC计划由NIH国家研究资源中心(NCRR)支持，并通过U42合作协议组织，这些协议在行政和操作上将NCRR与位于美国西部(加州大学戴维斯分校)、中央(密苏里大学)和东部(北卡罗来纳大学教堂山和杰克逊实验室)的4个信息学、协调和服务中心(ICSC；杰克逊实验室)战略地联系起来。这种组织结构确保了突变小鼠品系的保护、保存和可用性，以供学术研究人员和2010年的营利性研究人员进行研究，并使NIH资助的研究人员能够以方便和经济高效的方式满足NIH资源共享的要求。在其运作的第11个年头，截至2010年4月1日，MMRRC(www.mmrrc.org)的库存已增长到2,234个突变和基因工程小鼠模型，要么作为活克隆保存，要么作为冷冻保存的种质保存，以及27,627个ES细胞系。2010年，通过增加国际公认的鼠标资源中心杰克逊实验室作为第四个MMRRC储存库，MMRRC计划得到了扩展。在最初的10年里，MMRRC最初的3个储存库总共处理了来自全球1430多家机构的2170名调查人员的6629份订单。超过325名研究人员和10个主要的NIH资助的资源模型开发项目使用MMRRC保存了他们的菌株和ES细胞系。这种规模的多机构、地区分布的项目需要频繁的沟通。每月的电话会议被用来协调运作；然而，年度会议对于提供足够的时间和面对面的互动来讨论长期战略至关重要，以确保MMRRC计划继续服务于科学界迅速发展的需求。这些年度会议对于解决许多业务、组织和政策问题以及制定战略以继续提高MMRRC计划的有效性也是非常宝贵的。因此，该提案要求提供18,030美元，以支持2011年5月在缅因州巴尔港杰克逊实验室举行的第9届MMRRC年度会议。这次会议将汇集来自4个资料库的首席调查人员和其他关键人员，以及ICSC、NCRR和其他NIH项目工作人员。本次会议的目标是：1)对MMRRC的运作和绩效指标进行批判性、客观性的审查和评估；2)讨论各个中心的研究目标和成果；3)制定战略，利用鼠标资源满足科学研究界的持续和不断变化的需求。MMRRC项目的持续增长和成功表明了这些年度会议的价值。) 公共卫生相关性(由申请者提供)：突变小鼠区域资源中心(MMRRC)是NIH支持的一个主要的国家突变小鼠档案和分发联盟，为生物医学研究社区提供宝贵的资源：转基因小鼠、冷冻保存材料、胚胎干细胞系、技术支持和增值服务。人类疾病的小鼠模型和基础生物医学研究对于理解受人类疾病影响的生物系统至关重要。有了测序的基因组和越来越复杂的干细胞技术来操纵它，小鼠仍然是生物医学研究最强大的模式生物。具有人类基因同源突变的基因工程小鼠模型对翻译和临床前研究至关重要。它们使科学家能够了解人类疾病的原因、病理和发展，以便为这些疾病制定预防战略或治疗方法。此外，疗法或药物可以在人体试验之前在老鼠模型上进行测试，以评估有效性和安全性。MMRRC组件之间的通信对于其在满足生物医学研究社区不断发展的需求方面继续取得成功至关重要。

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value-added services to the biomedical research community. The MMRRC Program is supported by the NIH National Center for Research Resources (NCRR) and is organized through U42 cooperative agreements that administratively and operationally link the NCRR with 4 repositories located strategically in the Western (University of California-Davis), Central (University of Missouri), and Eastern (University of North Carolina-Chapel Hill and The Jackson Laboratory) USA, and an Informatics, Coordination and Service Center (ICSC; The Jackson Laboratory). This organizational structure ensures the protection, preservation, and availability of mutant mouse strains for research by academic and, as of 2010, for-profit investigators and enables NIH-funded researchers to meet the NIH resource-sharing requirement in a convenient and cost-effective manner. In its 11th year of operation, the MMRRC (www.mmrrc.org), as of 1 April 2010, has grown to an inventory of 2,234 mutant and genetically engineered mouse models maintained either as live colonies or cryopreserved germplasm, and 27,627 ES cell lines. In 2010, the MMRRC program was expanded by adding The Jackson Laboratory, an internationally recognized mouse resource center, as the fourth MMRRC repository. During its first 10 years, the MMRRC's original 3 repositories together filled over 6,629 orders from 2,170 investigators at over 1,430 institutions worldwide. Over 325 investigators and 10 major NIH-funded resource model development programs have preserved their strains and ES cell lines using the MMRRC. A multi-institutional, regionally distributed program of this size requires frequent communication. Monthly teleconferences are used to coordinate operations; however, annual meetings are critical to provide sufficient time and face-to-face interactions to discuss long-term strategies to ensure that the MMRRC Program continues to serve the rapidly evolving needs of the scientific community. These annual meetings also are invaluable to address numerous operational, organizational, and policy issues and develop strategies to continue to enhance the effectiveness of the MMRRC program. Therefore, this proposal requests $18,030 to support the 9th Annual MMRRC Meeting in May 2011 at The Jackson Laboratory in Bar Harbor, Maine. This meeting will bring together the Principal Investigators and other key personnel from each of the 4 repositories and the ICSC, NCRR and other NIH Program staff. The goals of this meeting will be to 1) critically and objectively review and assess MMRRC operational and performance metrics, 2) discuss research goals and accomplishments of individual centers, and 3) develop strategies for meeting ongoing and evolving needs of the scientific research community using mouse resources. The continued growth and success of the MMRRC Program has shown the value of these annual meetings. ) PUBLIC HEALTH RELEVANCE (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides invaluable resources to the biomedical research community: genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value- added services. Mouse models for human disorders and for basic biomedical research are critical to understand biological systems affected by human diseases. With a sequenced genome and increasingly sophisticated stem cell technologies to manipulate it, the mouse remains the most powerful model organism for biomedical research. Genetically engineered mouse models with mutations in orthologs of human genes are critical for translational and pre clinical research. They enable scientists to understand the causes, pathologies and progression of human diseases so that prevention strategies or therapeutics for these diseases can be developed. In addition, therapies or drugs can be tested on mouse models prior to human trials to assess efficacy and safety. Communication among MMRRC components is critical for its continued success in meeting evolving needs of biomedical research community.