Simple Automatic Perfusion System for salvage after cardiac arrest

描述（由申请人提供）：体外支持（ECPR）将心脏骤停复苏的存活率从5%提高到30%。体外支持有助于心脏死亡（DCD）后供体器官的抢救。医学研究所的报告指出，挽救DCD器官的创新方法是器官移植的重中之重。然而，ECS很少用于这些应用。限制因素是需要一种简单的自动灌注系统，该系统本身安全，可由医护人员启动，并在没有操作员干预的情况下提供全面支持。MC3在开发这种设备方面具有独特的优势。密歇根大学的研究小组已经证明，ECPR是可行的，其结果是30%的健康存活率。同一个研究小组已经证明，心脏骤停死亡后的机械器官灌注（DCD-ECS）可以将肝脏和肾脏功能恢复到可移植状态。此外，在移植后，这些cd - ecs器官甚至比来自心脏跳动的脑死亡捐赠者的器官更成功。本研究项目的目标是设计和生产一种简单的体外支持自动灌注系统（APS），以促进心脏骤停后供体的ECPR和器官回收。

DESCRIPTION (provided by applicant): Extracorporeal support (ECPR) improves survival in resuscitation from cardiac arrest from 5% to 30%. Extracorporeal support facilitates the salvage of donor organs after cardiac death (DCD). The Institute of Medicine report states that innovative methods to salvage DCD organs are the highest priority in organ transplantation. However ECS is rarely used for these applications. The limiting factor is the need for a simple automatic perfusion system which is inherently safe, can be initiated by paramedical personnel, and provides full support without operator intervention. MC3 is uniquely positioned to develop such a device. The research team at the University of Michigan has demonstrated that ECPR is feasible and results in 30% healthy survival. The same team has shown that mechanical organ perfusion after death by cardiac arrest (DCD-ECS) restores liver and kidney function to transplantable status. Moreover, after transplantation these DCD-ECS organs are even more successful than organs from heart-beating brain dead donors. The goal of this research project is to design and produce a simple Automatic Perfusion System (APS) for extracorporeal support to facilitate ECPR and organ salvage from donors after cardiac arrest.