WASHINGTON UNIVERSITY PAUL CALABRESI CAREER DEVELOPMENT AWARD FOR CLINICAL ONCOLO

描述(申请人提供)：测序技术和生物信息学的进步现在使全面研究癌症基因组的复杂图景成为可能，这是前所未有的。新的靶点正在被确定，仅基于显微发现对癌症亚型进行分类的传统方法正在让位于分子基因分型。今天从事以患者为中心的癌症研究的研究人员需要熟练地将基因组分析中迅速出现的数据转化为临床数据。此外，临床研究人员应该接受充分的培训，以评估用于诊断和治疗的各种方式的比较有效性，以优化临床实践并遏制不断飙升的医疗费用。我们正在申请保罗·卡拉布雷西临床肿瘤学职业发展奖，通过培训精通当今面向患者的癌症研究的三个关键领域的下一代临床医生和研究人员来实现这些目标：癌症基因组学、转化医学/临床试验和比较有效性研究。 我们建议利用华盛顿大学(WU)的特殊资源，包括基因组研究所、西特曼癌症中心、临床研究培训中心和公共卫生研究所来培训被选入该计划的个人。吴临床肿瘤学(K12)Paul Calabresi职业发展计划的广泛目标是培养具有专业知识的新一代高技能调查人员，他们将做好充分准备，在这一令人兴奋的时期利用癌症基因组学的新兴信息体领导癌症研究。在这些优先事项中，我们将把我们的培训集中在三个关键领域，1)癌症基因组学、生物信息学、分析及其在以患者为中心的研究中的应用；2)转化医学，特别强调将迅速出现的基因组数据转化为临床；临床试验设计、执行和分析在这个个性化治疗的时代；3)比较有效性研究。为了促进这一点，PC学者将从吴PC CDP提供的三个选修课程中选择一个：癌症基因组学课程、转化医学/临床试验课程和CER课程。我们建议在吴临床肿瘤学K12计划之外，与CTSA和其他职业发展计划发展和领导协作学习网络，分享最佳实践和知识，并传播新的培训计划和课程，以扩大该计划的影响。吴PC学者和其他受益于该计划的研究人员将学习进行研究，提供新的信息，解决当前的证据差距，以及如何将这些知识转化为改善癌症患者的预后。 与公共健康相关：我们现在能够比以往任何时候都更准确地检测细胞内基因的变化。新药可以有效地阻断某些基因的功能，对一些癌症患者可能非常有效。癌症护理的费用正在增加。为了有效地解决所有这些问题，新一代调查人员将需要 接受本申请所建议的所有这些领域的培训。

DESCRIPTION (provided by applicant): Advances in sequencing technologies and bioinformatics have now made it possible to study comprehensively the complex landscape of the cancer genome as never before. Novel targets are being identified and conventional methods of categorizing cancer subtypes merely based on the microscopic findings are giving way to molecular genotyping. Investigators engaged in patient oriented cancer research today need to be adept in translating the rapidly emerging data from genomic analyses to the clinic. Furthermore, clinical investigators should be adequately trained to assess the comparative effectiveness of various modalities used for diagnosis and therapy to optimize clinical practice and contain the soaring health care costs. We are applying for the Paul Calabresi Career Development Award for Clinical Oncology to achieve these goals by training the next generation of clinician-investigators well versed in the three key areas relevant to patient oriented cancer research today: Cancer Genomics, Translational Medicine/Clinical Trials and Comparative Effectiveness Research. We propose to use the exceptional resources at Washington University (WU) including The Genomics Institute, Siteman Cancer Center, Clinical Research Training Center and Institute for Public Health to train the individuals selected for this program. The broad goal of the WU Clinical Oncology (K12) Paul Calabresi Career Development Program is to train a new generation of highly skilled investigators with specialized expertise who will be well prepared to lead cancer research during this exciting period with the emerging body of information from cancer genomics. Within these priorities we will focus our training in three key areas, 1) Cancer genomics, bioinformatics, analysis and their application in patient oriented research, 2) Translational Medicine with special emphasis on translating rapidly emerging genomic data to the clinic, clinical trial design, execution and analysis in this era of personalized therapy and 3 Comparative Effectiveness Research. To facilitate this, PC scholars will choose one of the three elective tracks offered by the WU PC CDP: Cancer Genomics track, Translational Medicine/ Clinical Trialist track and CER track. We propose to develop and lead collaborative learning networks with the CTSAs and other career development programs at WU to share best practices and knowledge and disseminate new training programs and curricula beyond WU Clinical Oncology K12 Program to broaden the impact of this program. WU PC scholars and other investigators benefitting from this program will learn to perform research that will provide new information addressing current evidence gaps and how to translate this knowledge into improvements in the outcomes of patients with cancer. PUBLIC HEALTH RELEVANCE: We are able to detect changes in the genes inside a cell more accurately now than ever before. Newer drugs that effectively block the function of certain genes can be quite effective in some patients with cancer. The costs of cancer care are increasing. To tackle all these issues effectively, the newer generation of investigators will need to be trained in all these areas as is being proposed in this application.