Late Transition Metal Catalysts for Organic Synthesis

描述（由申请人提供）：合理和可预测地制备功能化有机分子的能力，无论是单独还是在文库中，都是有机合成，药物化学和制药工业的核心。这项工作的目的是开发新的和/或改进的方法来形成碳氮和碳氧键。这项工作包括通过交叉耦合方法开发制备复杂杂环化合物的新策略和新技术，杂环化合物是药物化学和制药工业的基石。此外，从这项工作中获得的信息将有助于了解正在开发的过程的机制，以便提高我们正在研究的技术的改进速度。有机合成新方法的开发是整个有机化学领域发展的关键。这些反应对制药业至关重要。碳杂原子键形成的交叉偶联方法经常被制药工业用于制备具有更高效力和更少副作用的类似物。此外，所述方法可用于制备用于临床前和临床试验的大量新物质以及用于药物制剂的实际制造。目前正在发展的技术使这些重要的职能能够以比以前更迅速和有效的方式执行。此外，它们允许制备以前无法获得的新物质。这些新化合物有可能在药物化学和制药工业中具有重要的生理特性。此外，这些技术被学术界和工业界的研究人员用于生物有机和材料研究的各个领域，包括新感官材料的形成。

DESCRIPTION (provided by applicant): The ability to prepare functionalized organic molecules rationally and predictably, whether individually or in libraries, is central to organic synthesis, medicinal chemistry and the pharmaceutical industry. The aims of this work are to develop new and/or improved methods for the formation of carbon-nitrogen and carbon-oxygen bonds. Included in this work is the development of new strategies and techniques for the preparation of complex heterocycles, which are the building blocks of medicinal chemistry and the pharmaceutical industry, via cross-coupling methodology. Further, information gained from this work will help to understand the mechanism of the processes that are being developed in order to increase the rate of improvement of the techniques that we are studying. The development of new methods for organic synthesis is key to the development of the field of organic chemistry as a whole. These reactions are of critical importance to the pharmaceutical industry. Cross-coupling methods for carbon-heteroatom bond formation are regularly used by those in the pharmaceutical industry for the preparation of analogues with increased potency and reduced side effects. Moreover, the methods can be employed for the preparation of quantities of new substances for preclinical and clinical testing and for the actual manufacture of a pharmaceutical agent. The techniques that are being developed allow for these important functions to be carried out in a more rapid and efficient fashion than previously possible. Moreover, they allow for the preparation of new substances, which have previously been inaccessible. These new compounds have the possibilities of having physiological properties of great importance in medicinal chemistry and the pharmaceutical industry. Further these techniques are used by researchers in both academia and industry in a variety of areas of bioorganic and materials research including in the formation of new sensory materials. PUBLIC HEALTH RELEVANCE: The cross-coupling methods we are developing for carbon-heteroatom bond formation are regularly used by those in the pharmaceutical industry for the preparation of analogues with increased potency and reduced side effects. Moreover, the methods can be employed for the preparation of quantities of new substances for preclinical and clinical testing and for the actual manufacture of a pharmaceutical agent.