IBD and Mucosal Inflammation, Immunology, and Microbiology of the GI Tract

这项申请是为了竞争性地更新芝加哥大学消化疾病研究核心中心(DDRCC)，该中心自1990年以来一直存在。这个DDRCC的主要主题是炎症性肠病(IBD)和IBD相关领域的研究，包括免疫学、微生物学和G1炎症性疾病的遗传学。在过去的供资周期中，发改委的领导、行政结构和研究基础提供了一个稳定的基础，这有助于在发改委成员之间发展强大和互动的网络。该研究基地是高度多学科的，目前每年的直接成本总额为1160万美元，其中40%或465万美元由NIDDK支持。这一金额略高于上次竞争续签的报告金额。学术水平仍然很高，其中40%以上的出版物涉及DDRCC成员之间的共同作者。试点和可行性计划成功地促进了新研究人员的发展，并吸引了其他领域的知名科学家参与IBD的研究。其项目的新颖性和优点使其在获得随后的外部资金方面取得了很高的成功率。丰富方案为复员方案协调委员会成员提供了继续教育和培训，并通过其互动方案，出现了几项新的方案倡议。随着该领域的快速发展和新技术的出现，发改委成功地预测了发改委调查人员的需求和活动。集成翻译核心(取代临床组件)已成为DDRCC的主要基础，将临床研究和基础研究联系起来，并为协作翻译研究创造了前所未有的机会。宿主-微生物核心(以前的细胞生物学核心)提供了广泛的实验系统来了解宿主-微生物的相互作用，包括灵芝技术和研究肠道微生物组的新一代分子方法。基因组学和分子工程以及组织和细胞分析核心也得到了发展，提供了适用于以人为基础的实验研究的尖端技术。总而言之，发改委积极促进其成员之间的互动和合作。通过其具有成本效益的使能技术和服务，DDRCC一直是芝加哥大学在IBD和消化系统疾病方面的学术进步和发现的主要因素。

This application is for the competitive renewal of the Digestive Diseases Research Core Center (DDRCC) at the University of Chicago which has been in existence since 1990. The overarching theme of this DDRCC is the study of inflammatory bowel diseases (IBD) and IBD-related areas, including the immunology, microbiology, and genetics of Gl inflammatory disorders. Over the past funding cycle, the leadership, administrative structure, and research base of the DDRCC have provided a constancy that has been conducive to the development of robust and interactive networks among DDRCC members. The research base is highly multidisciplinary and currently has an annual total direct cost of $11.6 million, of which 40% or $4.65 million is supported by NIDDK. This amount is slightly greater than that reported for the last competitive renewal. The level of scholarship continues to be outstanding where over 40% of the resulting publications involve shared authorships among DDRCC members. The Pilot and Feasibility program has successfully promoted the development of new investigators and attracted established scientists from other fields to the study of IBD. The novelty and merits of their projects have led to a very high success rate in obtaining subsequent extramural funding. The enrichment program has provided continuing education and training for DDRCC members and, through its interactive programs, several new programmatic initiatives have emerged. With the rapid advances in the field and the emergence of new technologies, the DDRCC has successfully anticipated the needs and activities of DDRCC investigators. The Integrated Translational core (replacing the clinical component) has become a major underpinning of the DDRCC, linking clinical and basic research and creating unprecedented opportunities for collaborative translational research. The Host-Microbe core (formerly the Cell Biology core) provides a wide range of experimental systems to understand host-microbe interactions, including gnotobiotic mouse technology and new generation molecular approaches for studying the enteric microbiome. The Genomics and Molecular Engineering and Tissue and Cell Analysis Cores have also evolved to provide cutting edge technologies applicable to human-based and experimental research. In summary, the DDRCC has proactively promoted interaction and collaboration among its members. Through its cost-effective, enabling technologies and services, the DDRCC has been a major factor in the advancement of scholarship and discovery in IBD and digestive diseases at the University of Chicago.