Improved patient outcomes by early intervention with therapeutic cooling for patients with severe traumatic brain injury, and by optimising patient blood transfusion practice in critically ill patients.

首先，一项大型多中心试验（POLAR）将补充我之前在创伤性脑损伤（TBI）患者中的成功试验，并将确定在脑损伤后早期开始并在重症监护病房继续进行的主动治疗性冷却是否会实现其改善患者预后的承诺。其次，一项全国性的多中心试验（TRANSFUSE）将确定使用比通常储存时间更短的血液单位是否会改善患者的预后。

First, a large multicentre trial (POLAR) will complement my previous successful trials in traumatic brain injury (TBI) patients and will establish whether active therapeutic cooling, commenced early after brain injury and continued in intensive care units, will achieve its promise of improving patient outcomes. Second, a national multicentre trial (TRANSFUSE) will establish whether transfusing blood units with a shorter than usual storage time will improve patient outcomes.