Tissue Engineered Cartilage Repair

描述（由申请人提供）：这是经过深思熟虑和支持性审查后重新提交的研究项目提案，其中有三个独立的研究项目，由一个行政核心和四个技术核心支持。该研究项目使用最先进的组织工程来解决关节软骨修复的问题。整个提案的主题是：组织工程软骨的物理，化学和生物控制。这些方法侧重于基于细胞的技术，是这一调查领域20多年经验的产物。所有参与者之前都有过互动，本计划的形成源于这些正式和非正式的互动。长期目标是提供转化为软骨修复临床相关协议的技术。因此，临床医生，细胞和分子科学家和工程师整合成一个有凝聚力和互动的生物技术项目团队，为将我们的科学发现转化为临床方案提供了一个有效和高效的机制。这三个项目是：骨软骨组织发生的结构化微环境; II.仿生组织工程化关节软骨修复及III.全关节表面置换术。四个技术核心提供细胞（B）、生物反应器能力（C）、形态学处理和分析（D）以及生物力学分析（E）。管理核心组织所有计划参与者之间的互动，以及与提供关键专业知识以帮助指导计划的外部顾问的互动。虽然每个项目都可以独立进行，但参与者的开放和频繁互动为该计划增加了科学和临床价值。最后，每个技术核心都有一个服务（对项目）和一个研究部分，与提案的总体主题相关。提案中的新案文在页边空白处用竖线表示。Word软件在段落中添加了沿着，即使是微小的改动。

DESCRIPTION (provided by applicant): This is a resubmitted PROGRAM PROJECT proposal following a thoughtful and supportive Review that has three separate research Projects that are supported by an Administrative Core and four technology Cores. The research Projects use state-of-the-art Tissue Engineering to address issues of articular cartilage repair. The entire proposal is centered on the theme of: Physical, Chemical and Biological Control of Tissue Engineered Cartilage. The approaches focus on cell-based technologies and are an outgrowth of over 20 years of experience in this investigative sector. All of the participants have previously interacted and the formation of this Program resulted from these formal and informal interactions. The long-term objective is to provide technologies that translate into clinically relevant protocols for cartilage repair. Thus, the integration of clinicians, cell and molecular scientists and engineers into a cohesive and interactive PROGRAM PROJECT team provides an effective and efficient mechanism for translating our scientific findings into clinical protocols. The three Projects are: I. Structured Microenvironment for Osteochondral Histogenesis; II. Biomimetic tissue-engineered articular cartilage repair and III. Total Joint Resurfacing. The four technology Cores provide cells (B), bioreactor capabilities (C), morphological processing and analysis (D), and Biomechanical analysis (E). The Administrative Core organizes the interactions between all Program participants and with outside Advisors who provide critical expertise to help guide the Program. Although each Project could stand alone, the open and frequent interactions of the participants adds substantial value both scientifically and clinically to the Program. Lastly, each of the technical Cores has both a service (to the Projects) and a research component that is relevant to the overall theme of the proposal. New text is indicated in the proposal by vertical lines in the margins. The Word software puts lines along paragraphs when even modest changes have been made.