Developmental Core

8.开发核心 以下章节描述了我们未来五年的主要发展活动。 8.a.教师招聘 确定教师招聘的优先事项： 在U 54规划过程的早期，我们成立了一个工作组，开始制定我们将 包括在我们的跨学科健康差异研究重点。跨学科工作队 2006年夏季和秋季举行的健康差距研究包括： 大卫朗斯伯里，MSKCC行为科学 <$玛丽阿尔堡，CCNY生物学<$Sara Olson，MSKCC流行病学 <$Carol Brown，MSKCC妇科肿瘤学<$Lucas Parra，CCNY生物医学工程 布鲁斯拉普金，MSKCC行为科学 <$Karen Hubbard，CCNY生物学<$Manish Shah，MSKCC胃肠病学 <$Edward Keller，CCNY媒体和<$Ann玛丽Yali，CCNY心理学 传播艺术<$Anne Zauber，MSKCC流行病学 <$Yuelin Li，MSKCC精神病学和生物统计学 该工作队提出了下述主题。每一个主题都被确定为一个领域， 由一个或两个机构的研究人员优先考虑。在某些情况下，我们没有教师合作伙伴 确定了在这两个机构的特定领域工作的人员。然而，通过定期的专题讨论会和 我们会继续进行规划工作，就以下各方面的持续发展提出建议： 基于社区的干预和传播研究 癌症治疗对神经认知的影响 生物标志物和遗传风险的前瞻性研究和识别 增加癌症临床试验患者的多样性 压力的生物心理社会研究 心理社会和行为干预的数学建模与仿真 U 54实施和教师搜索 U 54基金分配给癌症生物学教授 8.b.拟议试点项目 六个试点研究提案（项目2-7）包括在此叙述之后。这些项目高度 对伙伴关系目标和未来方向作出反应。Fu和Giancotti提出了一项基础研究， 检查乳腺肿瘤的粘连和外渗，这一系列研究将有助于解释 转移机制（项目4）。其中两个项目具有很强的临床相关性： Pezzano和圣安杰洛关于胸腺上皮祖细胞重建胸腺细胞的潜力的研究。 HSCT后的胸腺功能（项目6）以及Wang和Jiang在筛选抗癌药物方面的工作 项目7）。另外两个试点项目强调了解决癌症健康问题的尚未开发的潜力 在社区基础的初级保健实践中的差异。Ostroff和Lubetkin研究了 患者导航器可以增强和扩展提供者鼓励患者戒烟的努力 （项目5）。韦斯和宾兹-沙夫希望为初级保健医生提供知识和技能， 帮助他们的病人了解和考虑癌症诊断后的治疗性临床试验（项目3）。 哈伯德、阿勒斯和拉格纳特的研究源于我们的跨学科研究工作组， 研究与化疗引起的认知能力下降相关的遗传损伤（项目2）。两 这些试点团队（Fu/Giancotti和Pezzano/圣安杰洛）有着长期的合作关系。两 团队已经成功地获得了基于他们的Us 6飞行员的外部支持。这些飞行员 与这些团队早期的工作不同，以及生产线研究的逻辑下一步。 8.c.建议完整项目 我们的整个项目（项目i）源于我们两名高级研究人员的富有成效的合作： 阿夫罗姆·卡普兰和尼尔·罗森。该研究小组提出了一项研究，以检查使用Hsp 9 O分子 伴侣蛋白抑制剂促进癌细胞死亡。他们的项目支持伙伴关系的目标， 开展细胞生物学的转化研究，以支持癌症治疗的进展。 8.d.拟议资源/基础设施发展 培训和教育 外联

8. Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: ¿ Timothy Ahles, MSKCC Psychiatry ¿ David Lounsbury, MSKCC Behavioral Sciences ¿ Mary Alpaugh, CCNY Biology ¿ Sara Olson, MSKCC Epidemiology ¿ Carol Brown, MSKCC Gynecological Oncology ¿ Lucas Parra, CCNY Biomedical Engineering ¿ Jack Burkhalter, MSKCC Behavioral Sciences ¿ Bruce Rapkin, MSKCC Behavioral Sciences ¿ Karen Hubbard, CCNY Biology ¿ Manish Shah, MSKCC Gastroenterology ¿ Edward Keller, CCNY Media and ¿ Ann Marie Yali, CCNY Psychology Communication Arts ¿ Anne Zauber, MSKCC Epidemiology ¿ Yuelin Li, MSKCC Psychiatry and Biostatistics This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Neurocognitive Impacts of Cancer Therapeutics Participatory Research and the Identification of Biomarkers and Genetic Risks Increasing the Diversity of Patients on Cancer Clinical Trials Biopsychosocial Research on Stress Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions U54 Implementation and Faculty Search U54 Funds Allocated for Cancer Biology Professor 8.b. Proposed Pilot Projects Six pilot research proposals (Projects 2-7) are included after this narrative. These projects are highly responsive to Partnership objectives as well as future directions. Fu and Giancotti propose a basic study to examine adhesion and extravasation of mammary tumors, a line of research that will help to explain mechanisms of metastasis (Project 4). Two of the projects have strong potential for clinical relevance: Pezzano and Sant'Angelo's study of the potential for thymic epithelial progenitors to reconstitute of thymic function after HSCT (Project 6) and Wang and Jiang's work on screening anti-cancer agents Project 7). Two additional pilot projects emphasize the untapped potential to address cancer health disparities in that community-based primary care practices. Ostroff and Lubetkin examine whether patient navigators can enhance and extend providers' efforts to encourage patients to quit smoking (Project 5). Weiss and Binz-Sharf want to provide primary care doctors with knowledge and skills to help their patients understand and consider therapeutic clinical trials after a cancer diagnosis (Project 3). Hubbard, Ahles and Ragnauth's study grew out of our Task Force on Transdisciplinary Research, to examine genetic damage associated with chemotherapy induced cognitive decline (Project 2). Two of these pilot teams (Fu/Giancotti and Pezzano/Sant'Angelo) have long standing collaborations. Both teams have been successful in obtaining outside support based on their Us6 pilots. These pilots are different from these teams' earlier work, and logical next steps in productive lines of research. 8.c. Proposed Full Project Our full project (Project i) grows out of the productive collaboration of our two senior investigators: Avrom Caplan and Neal Rosen. This team proposes a study to examine the use of Hsp9O molecular chaperone inhibitors to promote cancer cell death. Their project supports the Partnership's objective to carry out translational research in cell biology to support advances in cancer treatment. 8.d. Proposed Resource/Infrastructure Development Training and Education Outreach