Pathogenesis of Infectious Diseases Training Program

描述（由申请人提供）：该计划的目标是培养生物医学研究人员，重点是医师科学家，从事基础和转化生物医学研究，重点是传染病的发病机制。该培训项目将利用威尔-康奈尔医学院、洛克菲勒大学和亚伦-戴蒙德艾滋病研究中心的资源。该项目的教师都是受资助的科学家，致力于研究和培训。六名新的潜在导师被纳入其中，他们都得到了NIH的独立研究支持。培训教员在通过国家卫生研究院福格蒂项目进行国际生物医学科学家的研究和培训方面有着悠久的成功合作历史，他们已将这一经验应用于美国医师科学家的培训。教员们一致认为，医生兼科学家确实是一个濒危物种，并致力于通过与博士后学员建立长期的指导关系来解决这个问题。研究培训的广泛领域是：病毒学、免疫学和与具有全球重要性的传染病有关的转化研究。学员有机会参加K30临床研究硕士课程，或酌情参加独立的研究生水平免疫学和分子生物学课程。在本资助期间（1999-2008年），已任命23名受训人员，17人已完成培训。其中10人获得了NIH“K”奖，1人获得了研究补助，2人获得了“K”奖。资助的研究领域包括KSHV-HHV8、HIV发病机制、HIV基因型耐药性、HCV-HIV合并感染、HIV- tb合并感染、多药耐药细菌、HIV疫苗开发、利什曼原虫发病机制和结核分枝杆菌- no相互作用。两名前学员已经获得了NIH“R”奖，两名在公共卫生领域担任要职（CDC， NYC）。有4名少数民族受训人员（3名非洲裔美国人，1名西班牙裔）和9名女性受训人员。该项目将继续招募完成临床培训（医学、儿科）并寻求学术研究事业的医生。这项培训补助金将为医生提供从临床培训过渡到实验室的机会。研究培训为期2-3年。

DESCRIPTION (provided by applicant): The objective of this program is to train biomedical researchers, with an emphasis on physician-scientists, in basic and translational biomedical research focusing on the pathogenesis of infectious diseases. The training program will utilize the resources of Weill Cornell Medical College, the Rockefeller University, and the Aaron Diamond AIDS Research Center. The program's faculty are funded scientists, committed to research and training. Six new potential mentors have been included, all with independent NIH research support. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs, and they have applied that experience to the training of US physician-scientists. The faculty members share the view that the physician-scientist is truly an endangered species and are committed to address this issue by establishing long-term mentoring relationships with postdoctoral trainees. The broad areas of research training are: virology, immunology, and translational research related to infectious diseases of global importance. Trainees have the opportunity to enroll in the K30 Masters in Clinical Investigation program or take independent graduate level immunology and molecular biology courses as appropriate. During the current funding period (1999-2008), 23 trainees have been appointed and 17 have completed training. Ten have received NIH "K" awards, one a research supplement, and two have "K" grants in preparation. The subject areas for the funded awards are KSHV-HHV8, HIV pathogenesis, HIV genotypic resistance, HCV-HIV coinfection, HIV-TB coinfection, multidrug resistance bacteria,-HIV vaccine development, leishmania pathogenesis and M. tuberculosis-NO interaction. Two former trainees have already received NIH "R" awards and two are in major public health positions (CDC, NYC). There have been four minority trainees (3 African-American, 1 Hispanic) and nine female trainees. The program will continue to recruit physicians who have completed their clinical training (medicine, pediatrics) and are seeking academic investigative careers. This training grant will provide physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years. RELEVANCE (See instructions): This training program will provide physician-scientists with the skills and mentoring needed to embark on successful careers conducting research in infectious diseases of public health importance both in the United States and worldwide. Specifically, the training will focus on tuberculosis, malaria, AIDS, hepatitis C virus, and potential agents of bioterrorism.