REDOX BIOCHEMISTRY
REDOX BIOCHEMISTRY
批准号:
8250451
负责人:
Vadim N. Gladyshev
金额:
$19.37万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-04-01 至 2015-03-31
关键词:
AlkylationAreaBiochemistryBioinformaticsBiological AssayBiological ModelsBiologyCell Culture SystemCell ExtractsCell NucleusCellsClinicalCollectionComplementConsultationsCytosolDisulfidesEndoplasmic ReticulumEndothelial CellsEquipmentF2-IsoprostanesFluorescenceFunctional disorderGene Expression ProfileGlutathioneGlutathione DisulfideGoalsHomeostasisHuman ResourcesHydrogen PeroxideIndividualInvestigationKnowledgeLabelLeadershipLinkLungMeasurementMeasuresMetabolicMetabolismMethodsMitochondriaMitochondrial MatrixMonitorMusNADPOxidation-ReductionOxidoreductasePeroxidesProcessProteinsProteomeReagentRegulationResearchResearch PersonnelServicesSignal TransductionStructureSulfhydryl CompoundsSystemThioredoxinbasedesignenzyme activitygenetic manipulationglutathione peroxidaseimprovedinstrumentationmethionine sulfoxide reductaseoverexpressionoxidant stressratiometricresearch studyselenoproteinsensorthioredoxin reductasetool
中文摘要
背景和意义
PPG中的所有四个项目都需要硫醇氧化还原调节和/或硒蛋白方面的专业知识。拟议的核心C领导层在这些领域以及总体上的合作研究方面有着良好的记录。Core C是世界上少数几个拥有必要的知识、专业知识、仪器和试剂来开展基于硫醇的氧化还原过程和硒蛋白质的实验的组织之一;并且拥有一系列独特的工具来完成这项工作。核心将协助相关实验的设计和解释。
英文摘要
BACKGROUND AND SIGNIFICANCE
All four Projects in the PPG require expertise in thiol-based redox regulation and/or selenoproteins. The proposed Core C leadership has a strong track record in precisely these areas, as well as in collaborative research in general. Core C is among the few groups in the world with the necessary knowledge, expertise, instrumentation, and reagents to carry out experiments on thiol-based redox processes and selenoproteins; and has a collection of unique tools by which to do so. The Core will aid in the design of relevant experiments and their interpretation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Profiling epigenetic age in single cells and in a high-throughput manner
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Role of rare damaging mutations in aging
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批准号:10225348
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批准号:10672456
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Role of rare damaging mutations in aging
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财政年份:2020
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依托单位:
Unbiased identification of interventions that extend lifespan
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批准号:10674697
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资助金额:$68.03万
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财政年份:2019
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依托单位:
Unbiased identification of interventions that extend lifespan
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批准号:9790603
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项目类别:
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资助金额:$72.82万
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财政年份:2019
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依托单位:
Unbiased identification of interventions that extend lifespan
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依托单位:
Unbiased identification of interventions that extend lifespan
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项目类别:
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资助金额:$72.36万
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财政年份:2019
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依托单位:
Unbiased identification of interventions that extend lifespan
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批准号:10019456
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项目类别:
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资助金额:$67.24万
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财政年份:2019
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负责人:Vadim N. Gladyshev
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依托单位:
Systems level understanding of selenoprotein biosynthesis
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批准号:9891054
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项目类别:
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资助金额:$47.22万
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财政年份:2018
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负责人:Vadim N. Gladyshev
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依托单位:
Systems level understanding of selenoprotein biosynthesis
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批准号:10392412
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项目类别:
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资助金额:$47.22万
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财政年份:2018
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依托单位:
Comparative genomics and epigenomics of aging
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项目类别:
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财政年份:2014
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依托单位:
Comparative genomics and epigenomics of aging
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项目类别:
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资助金额:$41.89万
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财政年份:2014
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依托单位:
Comparative genomics and epigenomics of aging
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项目类别:
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资助金额:$41.9万
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财政年份:2014
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依托单位:
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项目类别:
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财政年份:2013
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依托单位:
Mechanisms of lifespan control
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依托单位:
国内基金
海外基金
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负责人:史树中
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依托单位: