The District of Columbia Developmental Center for AIDS Research (DC D-CFAR)

描述（由申请人提供）：本申请描述了我们关于建立哥伦比亚特区艾滋病研究发展中心（DC - cfar）的建议。尽管美国首都的疫情非常严重，但美国国立卫生研究院从未在华盛顿特区资助过CFAR。DC - D-CFAR将是HIV/AIDS研究所的一个分支，该研究所成立于2006年，代表了80多名在华盛顿特区从事HIV/AIDS研究、临床护理和教育工作的教员。该研究所已经建立了艾滋病毒/艾滋病研究、教育和服务活动的坚实基础，这些活动将成为大大扩大儿童发展和预防艾滋病方案活动组合的基础。DC - cfar的目标是：1)领导推动华盛顿特区的艾滋病毒/艾滋病研究；2)促进华盛顿特区初级、少数族裔和新晋HIV/AIDS调查人员的发展；3)通过资助、专业网络和科学领导，加强华盛顿艾滋病研究人员之间的联系和合作。DC D-CFAR将处理国家CFAR方案的总体任务和目标，重点关注华盛顿特区疫情的独特方面，以及当地学术机构和调查人员的优势。参与DC - cfar的机构有：国家儿童医疗中心；乔治敦大学;乔治华盛顿大学公共卫生与卫生服务学院、医学与卫生科学学院和哥伦比亚文理学院；霍华德大学;以及退伍军人医疗中心执行委员会包括来自这些机构的主要艾滋病毒/艾滋病调查人员。惠特曼沃克诊所（Whitman Walker Clinic）和Unity Health care这两家主要的社区艾滋病毒/艾滋病护理提供者也同意参加DC - D-CFAR。Alan Greenberg博士是GW SPHSS流行病学和生物统计学系主任，也是艾滋病毒/艾滋病研究所的联合主任，他是拟议的DC - D-CFAR的首席研究员。DC - D- cfar将有五个核心-核心A行政，核心B发展，核心C临床，核心D基础科学，核心E公共卫生和政策。DC - cfar将包括三个咨询委员会：由每个DC合作机构的高级领导组成的监督委员会；由其他cfr核心董事组成的科学咨询委员会；以及由华盛顿特区主要艾滋病毒/艾滋病社区组织领导的社区咨询委员会。正如所附的支持函所反映的那样，哥伦比亚特区领导（市长、卫生部主任和艾滋病毒/艾滋病管理局高级副主任）、主要社区组织以及每一个合作机构都大力支持哥伦比亚特区方案。

DESCRIPTION (provided by applicant): This application describes our proposal to establish the District of Columbia Developmental Center for AIDS Research ("DC D-CFAR"). Despite the severity of the epidemic in our nation's capital, there has never been a NIH-funded CFAR in Washington DC. The DC D-CFAR would be an outgrowth of the HIV/AIDS Institute, an organization founded in 2006 which represents more than 80 faculty members working in HIV/AIDS research, clinical care and education in Washington DC. The Institute has built a strong base of HIV/AIDS research, educational and service activities which would serve as the foundation for a greatly expanded portfolio of DC D-CFAR activities. The Aims of the DC D-CFAR are to 1) Provide leadership to advance HIV/AIDS research in Washington DC; 2) Promote the development of junior, minority, and new HIV/AIDS investigators in Washington DC; and 3) Increase connectivity and collaboration among HIV/AIDS investigators in Washington DC through funding, professional networking, and scientific leadership. The DC D-CFAR would address the overall mission and goals of the national CFAR Program, with a focus on the unique aspects of the epidemic in Washington DC, and on the strengths of local academic institutions and investigators. The institutions participating in the DC D-CFAR are the Children's National Medical Center; Georgetown University; George Washington University (GW) School of Public Health and Health Services (SPHHS), School of Medicine and Health Sciences, and Columbian College of Arts and Sciences; Howard University; and the Veterans Affairs Medical Center. The Executive Committee includes leading HIV/AIDS investigators from each of these institutions. Two major community-based HIV/AIDS care providers, the Whitman Walker Clinic and Unity Health Care, have also agreed to participate in the DC D-CFAR. Dr Alan Greenberg, Chair of the GW SPHSS Department of Epidemiology and Biostatistics, and Co-Director of the HIV/AIDS Institute, is the Principal Investigator of the proposed DC D-CFAR. The DC D-CFAR would have five Cores - Core A Administrative, Core B Developmental, Core C Clinical, Core D Basic Science, and Core E Public Health and Policy. The DC D-CFAR will include three Advisory Committees: the Oversight Committee with senior leadership from each of the collaborating DC institutions; the Scientific Advisory Committee composed of Core Directors from other CFARs; and the Community Advisory Board with the leadership of the major HIV/AIDS community-based organizations in Washington DC. As reflected in the accompanying letters of support, the DC D-CFAR has received strong support from the leadership of the District of Columbia (Mayor, Department of Health Director, and HIV/AIDS Administration Senior Deputy Director), from major community-based organizations, and from each of the collaborating institutions. CORE A: Title: - Administrative Core Project Leader: Greenberg, A. CORE A DESCRIPTION (provided by applicant): The Administrative Core will lead and govern the District of Columbia Developmental Center for AIDS Research (the "DC D-CFAR") to address the overall mission and goals of the national CFAR Program, with a focus on the unique aspects of the DC D-CFAR - addressing the severe HIV/AIDS epidemic in Washington DC; developing HIV/AIDS research capacity among investigators, with a focus on junior and minority investigators, from the major academic institutions in the nation's capital; and capitalizing on the existing infrastructure and programs of the HIV/AIDS Institute. The specific aims of the Administrative Core include the following: 1. Provide leadership and governance of the DC D-CFAR 2. Promote multidisciplinary and multi-institutional scientific HIV/AIDS research and educational activities 3. Ensure the responsible oversight and management of all DC D-CFAR fiscal and personnel resources 4. Ensure the continuous quality improvement of DC D-CFAR scientific and educational activities The Administrative Core will provide the leadership and infrastructure necessary for the Developmental and three Scientific Cores to function effectively in their promotion and delivery of research related to HIV/AIDS. Upon notification of funding, the Administrative Core would immediately facilitate the transition to a DC DCFAR. Throughout this transition the necessary steps would be taken to implement the fiscal mechanisms that will allow our multi-institutional D-CFAR to function; notify all Core Directors and Advisory Committee members about the award funding and the transition plan; and communicate with all members, potential Core users and other key stakeholders about the institution of the D-CFAR in Washington DC. Thereafter, the Administrative Core would continue to provide oversight and to manage the functioning of the DC D-CFAR through ongoing meetings, educational seminars, communication mechanisms, grant management, fiscal oversight and monitoring and evaluation activities that would allow for the continual growth of the DC D-CFAR as it builds the foundation necessary to function as a full CFAR in the future.