Biostatistics and Bioinformatics

胃肠道生物统计学和生物信息学核心（GI-BBC）的目标是为GI SPORE提供广泛，高质量的统计和生物信息学支持。GI-BBC的主要目的是协助GI SPORE研究者设计、实施和分析本SPORE申请中提出的实验室和临床研究。GI-BBC将致力于协助临床和实验室研究人员将其临床前研究转化为临床研究，通过统计咨询和在方法学、可行性、分析和临床和实验室研究报告方面的合作，提供最先进的实验设计和分析。此外，GI-BBC将作为所有GI-SPORE调查人员的持续资源。核心将由Klein博士领导，并配备三名额外的教职员工作为共同研究者：Hao Wang博士，Rachel Karkin博士和加里罗斯纳。这些GI-BBC的教职员工有互补的专业领域：克莱因博士在流行病学和统计遗传学。Rosner博士在生物统计学和临床试验。王博士在临床试验和纵向建模，和Karkin博士在计算遗传学。癌症中心的生物统计学家Marianna Zahurak女士将协助Klein、Rosner和Wang博士进行统计分析。将统计需求集中在GI-BBC核心内，将使统计研究和评价中心的调查人员能够公开接触到一个统计人员小组，该小组具有以具有成本效益的方式实现统计研究和评价中心当前和未来目标所需的技能。此外，它还将促进SPORE项目之间的沟通，帮助将研究结果转化为临床环境。

The goal of the Gastrointestinal Biostatistics and Bioinformatics Core (GI-BBC) is to provide wide-ranging, high-quality statistical and bioinformatics support to the GI SPORE. The primary aim of the GI-BBC is to assist GI SPORE investigators in the design, conduct and analysis of laboratory and clinical studies proposed in this SPORE application. The GI-BBC will focus its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinic studies into clinical studies by providing state-of-the-art experimental designs and analyses through statistical consultation and in collaboration with respect to methodology, feasibility, analysis, and reporting of clinical and laboratory studies. In addition, the GI-BBC will serve as an ongoing resource for all GI-SPORE Investigators. The Core will be led by Dr. Klein and staffed with three additional faculty members as co-investigators: Drs. Hao Wang, Rachel Karchin, and Gary Rosner. These GI-BBC faculty members have complementary areas of expertise: Dr. Klein in epidemiology and statistical genetics. Dr. Rosner in biostatistics and clinical trials. Dr. Wang in clinical trials and longitudinal modeling, and Dr. Karchin in computational genetics. Ms. Marianna Zahurak, a biostatistician in the Cancer Center, will assist Drs. Klein, Rosner, and Wang in statistical analyses. Centralization of statistical needs within the GI-BBC core will provide SPORE investigators with open access to a team of statisticians with the skill set necessary to meet the current and future goals of the SPORE in a cost-effective manner. In addition, it will facilitate communication across SPORE projects, aiding the translation of research findings into the clinical setting.