Genetics Core

遗传学核心设施是华盛顿大学风湿病核心中心(RDCC)的研究核心之一。它提出了以下具体目标，以维持和发展向RDCC成员提供的新的最先进的蛋白质服务：1)支持转基因和基因敲除小鼠设施的持续进步和发展；2)支持小鼠速度遗传设施的持续进步和增长；以及3)支持新的人类基因组和生物信息学设施的开发和使用。转基因和敲除小鼠设施帮助RDCC研究人员通过显微注射转基因构建物或胚胎干细胞来培育新的小鼠品系。SpeedCongenics设备提供定制的基因分型，以加快将具有定义的等位基因的小鼠回交到同质遗传背景上。新的人类基因组和生物信息学设施将提供设计和解释高通量遗传学信息的专业知识。所有单位都致力于测试新技术，以便为RDCC社区提供新工具。

The Genetics Core facility is one of the research cores in the Rheumatic Diseases Core Center (RDCC) at Washington University. It proposes the following Specific Aims to sustain and develop new state-of-the-art protein services to RDCC members: 1) Support continued progress and growth of the Transgenic and Knockout Mouse Facility; 2) Support continued progress and growth of the mouse Speed Congenics Facility; and 3) Support development and use of a new Human Genomics and Bioinformatics Facility. The Transgenic and Knockout Mouse Facility helps RDCC investigators produce new strains of mice by microinjection of transgenic constructs or embryonic stem cells. The Speed Congenics Facility provides custom genotyping to speed backcrossing of mice with defined alleles onto homogeneous genetic backgrounds. The new Human Genomics and Bioinformatics Facility will provide expertise in design and interpretation of high throughput genetics information. All units are devoted to testing new techniques in order to provide the RDCC community with new tools.