Jaks and Stats: Development to Disease

描述(申请人提供)：对Jak-Stat信号通路的研究现已达到极其复杂的水平。然而，无论是涉及新的途径成分还是已知途径成分的新作用，对Jak-Stat途径和其他信号途径的信号都有深刻的影响，新的重要见解继续迅速涌现。最近的工作也表明，Jak和Stats是进化上保守的信号分子，调节从干细胞更新和胚胎发生到器官发生和造血细胞和淋巴样细胞的发育等一系列不同的基本过程。此外，它们在预防或促进传染病、恶性疾病和自身免疫疾病方面的作用现在已经成为密集研究的领域，在这些领域取得了令人兴奋的新发现，这些领域具有广泛的生物学应用。本次会议的目标如下：(1)确定Jak-Stat通路成员之间不仅相互作用，而且与其他信号转导通路的受体和组件之间的新的相互作用，特别强调调节Jak-Stat通路信号的正负作用机制；(2)确定Jak-Stat通路及其组成部分在原始和高等生物体发育中的作用，特别强调模式遗传生物以及造血和免疫系统；以及(3)讨论Jak-Stat信号通路在传染病和肿瘤疾病中的各种保护和促进疾病的作用。

DESCRIPTION (provided by applicant): The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid ceils. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: (1) Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling; (2) Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems; and (3) Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.