Metabolic Skeletal Disorders Training Program Grant

描述（由申请人提供）：华盛顿大学医学院及其附属的巴恩斯-犹太医院在肌肉骨骼研究、患者护理、教育和培训方面有着悠久的卓越传统。在过去的40年里，骨与矿物质疾病学部的成员和来自其他学部和部门的相关研究者组成了一个广泛的骨生物学项目，为致力于矿物质代谢疾病和骨骼疾病的研究者和临床医生提供了制度和人力资源支持。矿物质和骨骼代谢训练补助金，AR007033，连续资助了30多年，直到2004年，是完成我们教学任务的基础。在这个新的提议中，我们寻求重新建立一个跨学科的，制度性代谢骨骼疾病培训计划（MSDTP），以指导和培训下一代科学家和临床科学家在骨骼研究中，建立在我们机构的人才深度。该计划将在5个主题领域提供博士后和博士后培训：1)成骨谱系生物学；2)破骨细胞生物学与炎性骨骼疾病；3)转移性骨病；4)骨骼发育与修复；5)骨骼疾病的遗传学。这些主题代表了参与该培训计划的教师的重点，并反映了每个研究小组的共同兴趣和互动。入选MSDTP的受体来自华盛顿大学的5个院系（内科、骨科外科、病理与免疫学、发育生物学、解剖与神经生物学），反映了广泛的研究兴趣，包括骨骼发育、成骨细胞、破骨细胞和软骨细胞生物学、细胞信号传导、干细胞和结构生物学、骨免疫和造血系统相互作用、生物力学、异位钙化、以及小鼠和人类遗传学，骨转移和炎症性骨溶解。培训将包括4个部分：1)指导研究培训；2)核心课程课程作业；3)职业发展课程；表达和报告能力。博士后培训计划将提供基础科学或转化/临床导向的途径。博士预科课程将与生物与生物医学科学部（DBBS）管理的博士和医学博士/博士课程相结合，DBBS负责管理华盛顿大学的研究生课程。一个精简但重点突出的行政机构将管理培训生的招聘、任命和进展，并监督项目的成功。该项目以强有力的跨部门和全校支持为基础，将利用现有的机构基础设施，如骨和矿物质疾病科（资源和设施）、DBBS（培训生招聘和课程）以及转化和临床科学研究所（核心、服务和正式培训）。培养下一代医生和科学家对骨骼生物学研究的持续发展至关重要。这些研究对于了解骨骼疾病的遗传和分子基础，以及为骨质疏松、炎症性骨溶解、骨关节炎、肌腱衰竭和骨转移等疾病制定新的治疗策略是必要的，这些疾病困扰着很大一部分老年人。

DESCRIPTION (provided by applicant): Washington University School of Medicine and the affiliated Barnes-Jewish Hospital have a long tradition of excellence in musculoskeletal research, patient care, education and training. During the past 40 years, a broad program in bone biology consisting of members of the Division of Bone and Mineral Diseases and associated investigators from other Divisions and Departments have provided the institutional and human resources in support of investigators and clinicians committed to diseases of mineral metabolism and skeletal disorders. A Mineral and Skeletal Metabolism Training Grant, AR007033, was continuously funded for more than 3 decades, and until 2004, was fundamental to accomplishing our teaching mission. In this new proposal, we seek to re-establish an interdisciplinary, institutional Metabolic Skeletal Disorders Training Program (MSDTP) to mentor and train the next generation of scientists and clinician-scientists in skeletal research, building upon the depth of talent at our institution. This program will offer pre- and post-doctoral training in 5 thematic areas: 1) Biology of the osteogenic lineage; 2) Osteoclast biology and inflammatory skeletal disorders; 3) Metastatic bone disease; 4) Skeletal development and repair; 5) Genetics of skeletal disorders. These themes represent the focus of the faculty participating in this training program and reflect common interests and interactions within each research group. The pool of Preceptors selected for this MSDTP are drawn from 5 academic Departments at Washington University (Internal Medicine, Orthopaedic Surgery, Pathology and Immunology, Developmental Biology, and Anatomy and Neurobiology) and reflects broad research interests, including skeletal development, osteoblast, osteoclast and chondrocyte biology, cell signaling, stem cell and structural biology, bone-immune and hematopoietic system interactions, biomechanics, ectopic calcification, as well as mouse and human genetics, bone metastasis and inflammatory osteolysis. The training will consist of 4 components: 1) mentored research training; 2) core curriculum coursework; 3) career development coursework; 4) presentation and reporting skills. The post-doctoral training program will offer either a basic science- or a translational/clinical- oriented pathway. The pre-doctoral training pathway will be integrated with the PhD and MD/PhD programs administered by the Division of Biology and Biomedical Sciences (DBBS), which manages the graduate programs at Washington University. A streamlined but focused administrative structure will manage trainee recruitment, appointment and progress and monitor the program success. The program, which builds on strong interdepartmental and School-wide support, will leverage on existing institutional infrastructure, such as the Division of Bone and Mineral Diseases (for resources and facilities), the DBBS (for trainee recruitment and coursework), and the Institute for Translational and Clinical Sciences (for cores, services and formal training). Training the next generation of physicians and scientists is paramount to the continuous growth of research on skeletal biology. Such research is necessary to understand the genetic and molecular bases of skeletal disorders, and to devise new treatment strategies for diseases such as osteoporosis, inflammatory osteolysis, osteoarthritis, tendon failure, and bone metastasis, which afflict a large proportion of the elderly population.